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Common Adjuvant Regimens PowerPoint PPT Presentation


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Taxanes  — Taxanes are among the most active agents for metastatic breast cancer – Docetaxel, Paclitaxel, NabPaclitaxel. Anthracyclines – Doxorubicin, Epirubicin, Caelyx. Capecitabine / 5 FU Eribulin Vinorelbine Gemcitabine Ixabepilone Etoposide Cyclophosphamide Methotrexate

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Common Adjuvant Regimens

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Common adjuvant regimens

Taxanes — Taxanes are among the most active agents for metastatic breast cancer – Docetaxel, Paclitaxel, NabPaclitaxel.

Anthracyclines – Doxorubicin, Epirubicin, Caelyx.

Capecitabine / 5 FU

Eribulin

Vinorelbine

Gemcitabine

Ixabepilone

Etoposide

Cyclophosphamide

Methotrexate

Platinum agents

Combination Chemotherapy

High Dose Chemotherapy and Stem Cell Transplant – no benefit.


Common adjuvant regimens

Common Adjuvant Regimens

20%

20%


Common adjuvant regimens

Doxorubicin 60 mg/m2 IV Day 1

Cyclophosphamide600 mg/m2 IV Day 1

Every 21 days x 4 cycles

RANDOMIZE

Docetaxel 75 mg/m2 IV Day 1

Cyclophosphamide600 mg/m2 IV Day 1

Every 21 days x 4 cycles


2 nd generation adjuvant chemo trials

2nd Generation Adjuvant Chemo Trials


What s the goal

What’s the Goal?

  • Select patients who will require systemic therapy

  • Find predictive factors (either before or early in treatment) that allow for accurate tailoring of therapy


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