Familial hypercholesterolemia
This presentation is the property of its rightful owner.
Sponsored Links
1 / 29

Familial Hypercholesterolemia PowerPoint PPT Presentation


  • 139 Views
  • Uploaded on
  • Presentation posted in: General

Familial Hypercholesterolemia.   تاریخچه :

Download Presentation

Familial Hypercholesterolemia

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Familial hypercholesterolemia

Familial Hypercholesterolemia


Familial hypercholesterolemia

:

1938 1970-1980 FH . HMGCoA FH . LDL . FH . LDLR 1985 .


Familial hypercholesterolemia

Familial hypercholesterolemia FH LDL FH FH ( ) ( .) LDLR LDL Receptpr pr. LDL . Apo B LDL . .

LDLR 30-40 . .


Familial hypercholesterolemia

FH 500 . FH .

FH . FH LDLApheresis .


Familial hypercholesterolemia

:

. . (XanthelasmaPalpebrarum) (ArcusSenilisCorneae) (Tendon Xanthema).


Familial hypercholesterolemia

  • -:

    . FH ( ) . ( ) . FH . . .


Familial hypercholesterolemia


Familial hypercholesterolemia

) :

. arcus . FH 2 . LDL HDL .

75% LDL .

FH .


Familial hypercholesterolemia

) :

LDL LDL Apo B 50-80 . Combined Hperlipidemia .


Familial hypercholesterolemia

) :

FH Fmilial Combined Hyperlipidemia Polygenic Hypercholesterolemia . Xanthoma .Sitosterolemia CerebrotendineousXanthoma .


Familial hypercholesterolemia


Familial hypercholesterolemia

LDLRApo B PCSK9 LDLRAP1 . Sitosterolemia FH ABCG5 ABCG8 .


Familial hypercholesterolemia

  • LDL:

  • LDL 19 18 839 .FH 40% 50 . FH . LDL LDLR . LDLR 2% 2-25% 1000 .


Familial hypercholesterolemia

5 FH LDLR :

  • I:LDLR .

  • II:LDLR .

  • III:LDLR LDL AboB100 LDLR .

  • IV: LDLR LDL ( )

  • V:LDLR .


Familial hypercholesterolemia

Apo B:

ApoB100 . (P24-P23) 21.08-21.12 Mb .FH R3500Q 3500 . LDL . LDLR FH .


Familial hypercholesterolemia

  • PCKS9:

  • ARH LDLRAP1 1973 . FH ( ). . LDLR Clathrin-Coated Pit . LDLR LDLR .


Familial hypercholesterolemia


Familial hypercholesterolemia

LDL 2.5 LDLR .LDL HMG-CoA . FH LDLR LDL 4.5 LDL . ApoB LDL LDL . PCSK9 arh LDLR .


Familial hypercholesterolemia

  • FH LDL . LDLR . FH LDL . .

  • FH FH . (G20210A) FH . A . ACE .


Familial hypercholesterolemia

:

FH 16 . . 16 .


Familial hypercholesterolemia

  • Cure


Familial hypercholesterolemia

-FH :

FH HMG-CoA . LDLR LDL . LDL . . Bile AcideSequestrant ( ) ... . FH . . FH . ( )( ) LDL .


Familial hypercholesterolemia

Ezetimibe . LDL - . Ezetimibe FH .

FH . ( ). 1999 FH 1990 .


Familial hypercholesterolemia

2008 FH 44000 FH 48 . FH . 25% . FH .


Familial hypercholesterolemia

-FH :

FH . LDLR . . LDL Apheresis LDH . LDLR . ( ). PartiaIleal bypass PortoCaval Shunt .


Familial hypercholesterolemia

  • Limitapide Microsomal Triglyceride Transfer Pr. 2012 USFDA FH . 2013USFDA Mipomersen ApoB FH . ApoA1 .

    :

    FH . Bile Acid Sequestrant Fenofibrates . .


Familial hypercholesterolemia

:

FH 500 .FH 1000000 . LDLR . . . FH . ApoB .


Familial hypercholesterolemia

...

:

:

92


  • Login