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What’s New in Research at the Anschutz Medical Campus: Colorado Clinical Translational Sciences Institute. Ronald J. Sokol, MD Director Colorado Clinical and Translational Sciences Institute Professor and Vice Chair Department of Pediatrics, SOM. Oct., 2007.

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Ronald j sokol md director colorado clinical and translational sciences institute

What’s New in Research at the Anschutz Medical Campus:Colorado Clinical Translational Sciences Institute

Ronald J. Sokol, MD

Director

Colorado Clinical and Translational Sciences Institute

Professor and Vice Chair

Department of Pediatrics, SOM

Oct., 2007


Ctsa objectives speed discoveries to improved patient care

CTSA Objectives: Speed Discoveries to Improved Patient Care

  • Develop a distinct discipline for clinical and translational science at institutions

  • Provide opportunities and resources for original research on novel methods

  • Develop translational technologies and a knowledge base for the full spectrum of clinical and translational science

  • Synergize partnerships with industry, foundations, and community physicians

  • Train the interdisciplinary teams who will conduct the clinical and translational research of the future


Ronald j sokol md director colorado clinical and translational sciences institute

Bidirectional Translational Research

Clinical

Investigation

Clinical Trials

Practice

In the

Community

Basic

Research

T1

T2

Bench

Bedside

Trench

Molecules & Cells,

Animal Models

Patients

Community & Population


Nih ctsa awards a home for clinical and translational science

NIH CTSA Awards: A Home for Clinical and Translational Science

Trial Design

Industry

Clinical

Research

Ethics

Advanced

Degree-Granting

Programs

Biomedical

Informatics

CTSA

HOME

Other

Institutions

Clinical

Resources

Participant

& Community

Involvement

Biostatistics

Regulatory

Support

Housed in a Department, Center or Institute


Csta reorganizes current ucdhsc infrastructure

CSTA – Reorganizes Current UCDHSC Infrastructure

  • CTSA will subsume GCRC grants (M01), K30 grant – will end in 2010-11

  • These programs will be integrated into CTSA

  • Must develop a K12 program

  • Optional – new predoctoral T32 program

  • Adds many new programs

  • NIH to award 60 CTSA grants by 2011


Ten ctsa key functions new organization nih

Ten CTSA Key Functions(New Organization - NIH)

  • New translational and clinical methods development

  • Regulatory knowledge and support

  • Design, biostatistics and clinical research ethics

  • Translational technologies and resources


Ten ctsa key functions

Ten CTSA Key Functions

  • Pilot and collaborative translational and clinical studies

  • Participant and Clinical Interactions

  • Translational informatics

  • Community Engagement

  • Research Education, Training and Career Development

  • Evaluation and Tracking


Why a colorado ctsa

Why a Colorado CTSA?

  • Must be part of CTSA national program to have a voice in CTS research, shape national programs

  • Ability to attract and retain outstanding faculty, trainees and physicians at all affiliated institutions and campuses

  • Provision of essential infrastructure, support and improved training

  • Be eligible for special NIH funding (RFAs)


Current cts research and training strengths at ucdhsc and cu

Current CTS Research and Training Strengths at UCDHSC and CU

  • Many successful collaborative Translational research efforts across campuses

  • Outstanding clinical research facilities (two General Clinical Research Centers and two satellites) and core resources

  • Excellent community research programs (including Native American Health)

  • One of first Clinical Science PhD and Masters programs in U.S.

  • Strong Child Health Research Programs


Progress toward ctsa application

Progress toward CTSA Application

1. CTSA Planning Grant awarded in 2006

  • Funded – $150,000 direct costs $231,000 total costs

  • Major critiques:

    • Expand scope to include more collaboration with CU Boulder – Physiology, bioengineering, etc.

    • Evaluation process to assess outcomes resulting from infrastructure changes

      2. New Colorado CST Institute (CCTSI) approved by Regents in Aug. 2007

      3. Grant application – Nov. 7, 2007 deadline


Vision of cctsi

Vision of CCTSI

Transform the current clinical and translational research and training efforts of all Schools at UCDHSC and affiliated institutions into an innovative, interdisciplinary, collaborative campus-wide academic home for clinical and translational sciences, scientists and trainees


Mission of cctsi

Mission of CCTSI

Improve the health of the population of Colorado by catalyzing the translation of biomedical discoveries into prevention and intervention strategies in the community, and by reducing health care disparities


Goals of colorado ctsi

Goals of Colorado CTSI

  • Transformation of the Institution: UCDHSC will create the CCTSI as a visible, integrated and interdisciplinary statewide academic home for the disciplines of clinical and translational sciences and research that will remove barriers and obstacles and promote successful careers


Goals of colorado ctsi1

Goals of Colorado CTSI

2. Transformation of the Clinical and Translational Scientist:

The CCTSI will enhance, integrate and transform training of translational scientists to develop a new generation of investigators with advanced degrees, interdisciplinary and collaborative skills and a team approach to scientific investigation


Goals of cctsi

Goals of CCTSI

3. Transformation of Discovery Translational Research:

The CCTSI will transform the performance of discovery translational research (bench-to-beside research) by providing new resources and infrastructure, integrating current and developing new innovative research tools and methodologies, catalyzing new interdisciplinary research programs and removing barriers to efficiency


Goals of cctsi1

Goals of CCTSI

4. Transformation of Community Translational Research and Practice.

The CCTSI will transform community and population-based research by enhancing, extending and integrating community-based participatory research into programs that will engage community participation and develop novel methodologies for translation of scientific discoveries into clinical practice


Ronald j sokol md director colorado clinical and translational sciences institute

Colorado CTSI

Academic Home

Multi-Institutional Collaboration

Collaborative

Investigative

Teams

Biomedical

Discoveries

Graduate Degree

Programs

Education, Training

Career Development

Basic and

Engineering

Sciences

Discovery

Translation

Interdisciplinary

Research

Programs

Improved

Community

Health

Community

Translation

Clinical

Trials

Novel Methods

& Technology

Patient

Oriented

Research

New Generation

of Trainees

Child and

Maternal Health

Research

Teams and

Leaders of

The Future

Community

And Population

Sciences

Community

Physician

Outreach

Evaluation

And Improvement

Disadvantaged

Populations


Cctsi institutional members

CCTSI Institutional Members

  • UCDHSC Schools of Medicine, Nursing, Dental, Pharmacy, Graduate School, Public Health

  • CU Boulder, UCDHSC Denver Campus (e.g. Bioengineering),

  • Affiliated hospitals - UCH, TCH, DH, NJMRC, VAH, Kaiser Permanente

  • Graduate Training Programs


Ronald j sokol md director colorado clinical and translational sciences institute

CCTSI Organizational Structure and Governance

Chancellor of UCDHSC

Vice Chancellor

of Research

Vice Chancellor

of Health Affairs

Director

CCTSI

CFO

CCTSI

Advisory

Council

Executive Committee:

Director, 5 Co-Directors,

CFO, Chair of IAC

Internal

Advisory

Committee

External

Advisory Committee


Ronald j sokol md director colorado clinical and translational sciences institute

Chancellor of UCDHSC

Vice Chancellor

of Research

Vice Chancellor

of Health Affairs

Director CCTSI

Sokol

CFO

Executive Committee

FIVE PROGRAMS

Training and

Education

Discovery

Translation

Community

Translation

Novel Methods

& Technology

Child & Maternal

Research

Eckel

Kramer

Geraci

Steiner

Hay


Ronald j sokol md director colorado clinical and translational sciences institute

ACADEMIC HOME

Director

Sokol

Steiner

Eckel

Kramer

Geraci

Hay

Training and

Education

Discovery

Translation

Community

Translation

Novel Methods

& Technology

Child & Maternal

Research

Community

Engagement &

Research

Integrate

Programs

Throughout

TCH and other

Facilities

Predoctoral

Post-doc

Jr. Faculty

Career

Development

K30, T32, K12

CTRCs

Clinical Trials

CPC

Pharmaceutical

development

Design, Biostatistics,

Research Ethics

Regulatory

Novel Methods

Development

Pilot Projects

Translational Technology

Cores

Informatics


Timetable

Timetable

  • Working Groups for each key function for past 10 months

  • External Advisory Committee meeting July 23, 2007

  • Working Groups – final drafts submitted

  • Executive Committee finalizing and editing

  • Application Deadline: November 7, 2007


Summary

Summary

  • CTSA application is a exceptional opportunity to transform andcatalyze clinical and translational research and training across campuses of University of Colorado, Affiliated Hospitals and Organizations

  • Will take a University-wide and Hospital-wide partnerships

  • Will require broad faculty and institutional commitments


Contact

Contact

  • [email protected]

  • Phone:720 777-6669

  • Pager: 303-890-7744

  • http://ctsa1.uchsc.edu


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