BRIEF History of endocrinology. Iendocrinology.com. THREE PERIODS IN HISTORICAL DEVELOPMENT OF ENDOCRINOLOGY. DESCRIPTIVE PERIOD PERIOD OF ANALYTICAL ENDOCRINOLOGY CONTEMPORARY PERIOD/SYNTHETIC ENDOCRINOLOGY. I. DESCRIPTIVE PERIOD. Anatomical description.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
“THOUSANDS OF GOLD PRISCRIPTION” by SON SSU MO 695AD
a) if the woman vomits- she is pregnant
b) if only flatulence - never bear again
The skull- mummy
Cleaopatra (69 BC)
Considered to be symbol of beauty(MIDDLE AGES)
Alexandrians-III century bc-thymus
Galen -greek(AD 129 – 200) thyroid, pineal&pitutary
Bartolommeo eustachi-suprarenals-16th century
Paul langerhans (1847-1888)-insula of pancreas -1869
1880-Ivar Viktor Sandstorm , swedish medical student,described parathyroid
17th century William Harvey describes heart as a four chambered pump that moves blood through arteries and veins, not air.
Mid 1800s idea that circulating blood carries substances from one part of the body to a distant part where the substance exerts its effect.
SPECIAL PHYSIOLOGY OF ENDOCRINE GLANDS : THE HORMONES
John hunter(1728 – 1793)-1792
Arnold Adolph Berthold ( 1 803-1 86 1 ) -1849
Concept of internal secretion-established in scientific knowledge
The great triumvirate
1855-the glycogenic function of the liver; in the course of this he was led to the conclusion, which throws light on the causation of diabetes mellitus, that the liver, in addition to secreting bile, is the seat of an internal secretion, by which it prepares sugar at the expense of the elements of the blood passing through it
“lessons on experimental physiology”
1855- “Constitutional And Local Effects Of Disease Of Supra Renal Capsule”
Role of internal secretion is demonstrated through anatomical observations
Addisonian anemia/pernicious anemia
1855- Demonstrated that removal of the adrenal gland resulted in death, due to lack of essential hormones.
1856- Alfred Vulpian : discovered adrenaline /chromogen in the adrenal medulla
1905-ernest h starling
First to use the word hormone at royal college of physicians, in his Croonian lectures , HARMAO = GREEK VERB;HAVING PROPERTY OF STIMULATING
Harvey Williams Cushing "father of modern neurosurgery".
The connection between hormonal & nervous system: neurohumoral system
Hippocrates(460 BC – 370 BC) – disease of scyths: hypo-orchadism/climatic hypoovarism
Hypothyroidism-Earliest to studied
1850- TB Curling:
described role of thyroid in symptom complex of cretinism
1889- Oscar Minkowski in collaboration with Joseph Von Mering removed the pancreas from a healthy dog to test its assumed role in digestion.
1901- Eugene Opie, established the link between the Islets of Langerhans and diabetes
1906- George Ludwig Zuelzer was partially successful treating dogs with pancreatic extract but was unable to continue his work.
1921 - Nicolae Paulescu, a professor of physiology at the university of medicine and pharmacy in Bucharest was the first one to isolate insulin
1921 -Fedrickbanting meet JJR MacLeod, who supplied Banting with a lab at the University of Toronto, an assistant (medical student Charles Best), and 10 dogs, then left on vacation during the summer of 1921.
December 1921- Macleod invited the Biochemist James Collip, to help with this task, and, within a month, the team felt ready for a clinical test
January 11,1922, Leonard Thompson, a 14-year-old diabetic who lay dying at the Toronto general hospital, was given the first injection of insulin. However, the extract was so impure that Thompson suffered a severe allergic reaction, and further injections were canceled.
young girl aged 13 years suffering from diabetes. She weighs just 45lbs and her chances of surviving for much longer are very, very poor. She was one of the first patients to be treated with insulin extracted from the pancreases of slaughtered cattle.
spring of 1922- Best managed to improve his techniques to the point where large quantities of insulin could be extracted on demand, but the preparation remained impure.
1950’-The amino acid structure of insulin was characterized in the 1950\'s and
Student assistant Charles H. Best and Frederick G. Banting are standing on the roof of the medical building with one of the diabetic dogs used in their experiments with insulin