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Supplemental Figure 2

Supplemental Figure 2. A. B. C. D. E. F. H. G. I. K. L. J.

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Supplemental Figure 2

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  1. Supplemental Figure 2 A B C D E F H G I K L J Supplemental Figure 2. Representative H&E images (20x objective) of the orthotopic xenograft model including (A) viable primary tumor, (B) primary tumor with large area of geographic necrosis, (C) direct extension of tumor into spleen and distant metastatic tumor nodules involving (D) lung, (E) small bowel and (F) diaphragm. Representative sections of normal tissues with no histopathologic abnormalities are shown for mice sacrificed 28-32 days into their treatment course with (G-I) vehicle or (J-L) ICG-001. Sections include (G,J) small bowel, (H,K) colon and (I,J) liver showing no architectural or cytologic abnormalities to suggest cytotoxicity.

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