Pharmacokinetic Modeling (describing what happens). Volume of distribution. AKA “Apparent volume of distribution” The volume of fluid that appears to contain the amount of drug in the body May not be actual physiologic space(s) Relates amount to plasma concentration
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(describing what happens)
Much like row 4 of table
Much like row 2 or 3 of table
0% cleared from
Passes through liver in
100 % cleared from
Clearance is 0.5 ml/min
Concentration vs time points represent concentrations determined for samples taken from the tank.
Two oral dose forms of the same drug. F of the “open triangle” dose form is ½ the “filled triangle” dose form.
Equal bioavailability (same F) and Bioequivalent
Equal bioavailability (same F) and not Bioequivalent