Genome Research Institute University of Cincinnati. Genome Research Institute. Housed in facility donated by Aventis Pharmaceuticals ~360,000 sq. ft. of office, laboratory and vivarium space Currently houses 38 PIs, ~350 total researchers. GRI Capabilities. Research Programs
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University of Cincinnati
Cell & Animal
biotech and pharma
Target Identification & Validation Phase
Cell & Animal
High Throughput Screening, Medicinal Chemistry, Computation and Protein Phase
Phase 1 Clinicals
Licensing, Co-Development, Pharma Partner Phase
Plate::explorer + Opera imaging system ultraHTS system
Up to 100,000 samples/24 hours
Whole cell fluorescence assays
Cell viability, cell differentiation, cell
proliferation, cytotoxicity, apoptosis,
Cell signaling assays
Calcium flux, second messengers, ion channels,
Gene expression assays
Expression of house-keeping and reporter
genes, gene activity and protein regulation,
Membrane receptor assays
Ligand binding, receptor activation and
desensitization, translocation and endocytosis,
recruitment of signaling molecules
Target molecule redistribution
Neurite outgrowth, cell differentiation, cell
adhesion and spreading
Opera Imaging Reader
>50,000 multi-color data
>4 million structures
MW filterSolubility Filter
GRI Compound Library
targets against all commercially available compounds
of binding interactions.
using this as the basis for virtual screening.
Small Molecule Modeling
What can we provide?
What are we looking for?