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1994. “IkB concentrations in the salicylate cell extracts were the same as in control whereas IkB was reduced in activated cells without salicylate”. 20mM aspirin. NFkB NFkB. CREB. Not seeing the same inhibition profile as other antiinflammatory agents.

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slide2

1994

“IkB concentrations in the salicylate

cell extracts were the same as in control

whereas IkB was reduced in activated cells

without salicylate”

20mM aspirin

slide4

NFkB NFkB

CREB

Not seeing the same inhibition profile as other

antiinflammatory agents.

slide7

Other pathways

Effective [ASA] 1-5mM

slide12

“preincubation”

Inhibition of kinase activity [] dept. of aspirin

slide16

Familial Cylindromatosis

(benign tumors)

Usually on forehead

and scalp

Dominantly inherited

due to loss of the

tumor suppressor:

CYLD

slide17

Used siRNA to knockdown expression of CYLD

PMA (phorbol ester) stimulates NFkB via IkBalpha degradation

When “KD” CYLD - increased proliferation

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