Basic approaches in RISK ASSESSMENT. István Murányi Hungarian Cosmetic and Home Care Association. What is Risk Assessment?. RISK. DANGER. Danger (hazard) versus Risk. Danger Exposure or vulnerability to harm or risk. Risk The probability of a danger to occur.
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Basic approaches in RISK ASSESSMENT
Hungarian Cosmetic and
Home Care Association
Exposure or vulnerability to harm or risk.
The probability of a danger to occur.
Risk = Probability (exposure)x seriousness of aftermath
R = W K
Identify the hazards
Decide who might be harmed and how
Evaluate the risks and decide on precautions
Record your findings and implement them
Review your assessment and update if necessary
You need to find those sources, which mean danger and possibly can cause harm.
Basicly you can
Practically it is estimation of exposure
Identify and investigate all possible effects of risk sources onto human health and environment
Estimation of probability and seriousness of risks to happen in a certain circumstances, with given conditions.
This process is based on quantative, semi-quantitave (empiric or theoretical) estimation taking hazards, exposure routes into consideration.
Tier approach !
If you’ve gone over Step 3, you need to know:
Put these in a set of rules and make ensure to be followed.
Hard surface cleaner, spray, consumer use
Calculation MOE (Margin Of Exposure)
MOE = NOAEL (No observable adverse effect level ) / Exposure
Generally speaking objective is MOE > 100
Dermal exposure of spray painting during car body repair
Cleaning spray gun
placing collection medium against the skin or clothes and subsequently analysing it for its chemical content
1 Patch methods
The traditional patch size is 10 x 10 cm. Usually only one or two patches are attached under the clothing layer to measure actual exposure. After the sampling and analysis, the measured amount is related to the surface area of the corresponding body part. Materials may include surgical gauze, alpha-cellulose paper, charcoal, cotton gauze, polyurethane, and polypropylene
2 Whole-body methods
Lightweight disposable overalls, cotton overalls, and the like are used as samplers.
The actual exposure and efficiency of protective clothing can be measured with underclothing as a monitor.
The normal clothing of workers has also been used as monitors.
3 Glove method
Use of absorbent gloves, usually cotton liners, to measure the exposure of hands. They can be used in place of, underneath, or on the top of the protective gloves.
Gloves are easy to use in the field, and they efficiently collect residues that would otherwise be absorbed into the skin during the sampling period.
Gloves should not become saturated, and they should be replaced if soaked.
NOAEL (?) = 180 mg/kg/day =3 mg/kg/h =3000 µg/kg/h
For 60 kg bodyweight = 180000 µg/h – 10 (µg/cm2/h)
Dermal Exposure per body part (µg/cm2/h)
Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals REACH
Chemical Safety Assessment (CSA)
Chemical Safety Report (CSR)
Exposure Scenarios (ES)
REACH Annex XIII. For what?
Guidance on information requirements and chemical safety assessment
(European Union System for the Evaulation of Substances)
(Technical Guidance Document – repealed by REACH, but principle still applies)