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Lymph node pathology. Lymph node histology. Functions Filtration of lymph Processing of Ag Differentiation of lymphocytes. Secondary lymphoid follicle Germinal centre mantle. Terminology. Lymphadenopathy Lymphadenomegaly Lymphadenitis Lymphoproliferation Lymphoma

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Lymph node pathology

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Lymph node pathology


Lymph node histology

Functions

Filtration of lymph

Processing of Ag

Differentiation of lymphocytes


Secondary lymphoid follicle

Germinal centre

mantle


Terminology

  • Lymphadenopathy

  • Lymphadenomegaly

  • Lymphadenitis

  • Lymphoproliferation

  • Lymphoma

  • Enlargement of LN: inflammation

  • Tumor – primary/secondary


Lymphadenitisacute or chronic

Classification

predominant histologic pattern

etiology

Rarely biopsied


Lymphadenitis - etiology

MICROBIAL

  • viral

  • bacterial, mycobacterial

  • fungal

  • protozoal

    NONMICROBIAL - autoimmune

    storage dis.

    foreign mat.

    miscel.


Lymph node inflammation

Lymph node hyperplasia:

1. follicular

2. paracortical

3. sinuses

4. mixed patterns


Lymph node inflammation - patterns

  • Follicular hyperplasia

    bacteria, RA, HIV(early), syphilis,

    Castleman dis.

  • Paracortical hyperplasia

    viruses, dermatopathies, vaccination,

    drug hypersensitivity, Kikuchi, SLE,

    draining pus or carcinoma


Lymphadenitis - histological patterns

  • sinusoidal hyperplasia - lymphangiography, Whipple dis., sin. histiocytosis with massive lymphadenopathy, draining carcinoma

  • granulomas - TB, other mycobact., leprosy, Whipple, fungi, berylliosis, sarcoidosis,

  • Granulomatous-purulent:cat scratch, tularemia, lymphogr. venereum,Yersinia

  • mixed patterns: toxoplasmosis


Regressive transformation of germinal centres


Follicular hyperplasia


Progressive transformation of germianl centres


Sinus histiocytosis


Lepra - globi


Infectious mononucleosis


Cat scratch disease


Kikuchi lymphadenitis


Bartonella henselaeCt scratch disease


CMV


Kimura disease


Cryptococcosis


Atypical mycobacteriosis


Lymphogranuloma venereum


Mycobacterium TB


Pneumocystosis


Syphilis


TBC


Toxoplasmosis


Whipple disease


Sinus histiocytosis

with massive lymphadenopathy


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