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Lymph node pathology. Lymph node histology. Functions Filtration of lymph Processing of Ag Differentiation of lymphocytes. Secondary lymphoid follicle Germinal centre mantle. Terminology. Lymphadenopathy Lymphadenomegaly Lymphadenitis Lymphoproliferation Lymphoma

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Lymph node pathology

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Lymph node pathology l.jpg

Lymph node pathology


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Lymph node histology

Functions

Filtration of lymph

Processing of Ag

Differentiation of lymphocytes


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Secondary lymphoid follicle

Germinal centre

mantle


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Terminology

  • Lymphadenopathy

  • Lymphadenomegaly

  • Lymphadenitis

  • Lymphoproliferation

  • Lymphoma

  • Enlargement of LN: inflammation

  • Tumor – primary/secondary


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Lymphadenitisacute or chronic

Classification

predominant histologic pattern

etiology

Rarely biopsied


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Lymphadenitis - etiology

MICROBIAL

  • viral

  • bacterial, mycobacterial

  • fungal

  • protozoal

    NONMICROBIAL - autoimmune

    storage dis.

    foreign mat.

    miscel.


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Lymph node inflammation

Lymph node hyperplasia:

1. follicular

2. paracortical

3. sinuses

4. mixed patterns


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Lymph node inflammation - patterns

  • Follicular hyperplasia

    bacteria, RA, HIV(early), syphilis,

    Castleman dis.

  • Paracortical hyperplasia

    viruses, dermatopathies, vaccination,

    drug hypersensitivity, Kikuchi, SLE,

    draining pus or carcinoma


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Lymphadenitis - histological patterns

  • sinusoidal hyperplasia - lymphangiography, Whipple dis., sin. histiocytosis with massive lymphadenopathy, draining carcinoma

  • granulomas - TB, other mycobact., leprosy, Whipple, fungi, berylliosis, sarcoidosis,

  • Granulomatous-purulent:cat scratch, tularemia, lymphogr. venereum,Yersinia

  • mixed patterns: toxoplasmosis


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Regressive transformation of germinal centres


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Follicular hyperplasia


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Progressive transformation of germianl centres


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Sinus histiocytosis


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Lepra - globi


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Infectious mononucleosis


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Cat scratch disease


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Kikuchi lymphadenitis


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Bartonella henselaeCt scratch disease


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CMV


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Kimura disease


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Cryptococcosis


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Atypical mycobacteriosis


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Lymphogranuloma venereum


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Mycobacterium TB


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Pneumocystosis


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Syphilis


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TBC


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Toxoplasmosis


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Whipple disease


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Sinus histiocytosis

with massive lymphadenopathy


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