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TREATMENT OF ANAEMIA

TREATMENT OF ANAEMIA. BY : DR.ISRAA OMAR . IRON. Stored in the body as ferritin Deficiency result from negative iron balance due to depletion of stores and/or inadequate intake . Iron deficiency cause hypochromic microcytic anemia

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TREATMENT OF ANAEMIA

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  1. TREATMENT OF ANAEMIA BY : DR.ISRAA OMAR

  2. IRON • Stored in the body as ferritin • Deficiency result from negative iron balance due to depletion of stores and/or inadequate intake . • Iron deficiency cause hypochromic microcytic anemia • Ferrous compound are required for treatment of this form of anemia • GIT disturbance is the most common adverse effect of iron supplements • IV\IM preparations are also available.

  3. IRON • Iron sucrose can be given IV. • Severe acute toxic effects occur if large doses are ingested • Chronic iron toxicity can occur in patient with chronic blood transfusion like thalassemic patients or in case of hemochromatosis • The treatment of acute and chronic iron toxicity involve use of iron chelators like DESFERRIOXAMINE .

  4. FOLIC ACID • Deficiency occur when there is increase demand like during pregnancy and lactation ,reduced absorption by intestinal pathology or taking folate lowering drugs like methotrexate. • Deficiency lead to megaloblastic anemia. • It is well absorbed in the jejunum so it is given orally ;unless the cause of deficiency is not an intestinal pathology. • No known toxicities or side effects.

  5. Cynacobalamin B12 • Deficiency lead to megaloblastic anemia and result from : • Low dietary intake (the most common cause) • Poor absorption due to failure of production of intrinsic factor that is produced by gastric parietal cells (pernicious anemia). • Low intestinal uptake of the vitamin • Can be given orally , IM Or subcutaneously . • In case of pernicious anemia the treatment should be given for life .

  6. Erythropoietin • It is a hormone secreted by the kidney • It regulate blood cell formation and proliferation in the bone marrow • Human erythropoietin can be synthesized by r DNA technology . • Deficiency occur in patients with chronic renal failure • It can be administered IV but the subcutaneous route is more appropriate • Side effect include allergies ,headache, arthralgia and hypertension .

  7. Erythropoietin • Clinical uses: • Anemia of chronic renal failure • During chemotherapy of cancer • Prevention o anemia in premature babies • Anemia of AIDS • Anemia of chronic disease

  8. THANK YOU

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