This presentation is the property of its rightful owner.
Sponsored Links
1 / 95

第十五章 药物制剂的设计 PowerPoint PPT Presentation


  • 213 Views
  • Uploaded on
  • Presentation posted in: General

第十五章 药物制剂的设计. 复习. 举例说明流变学在药剂学(乳剂、混悬剂、软膏剂)中的应用? 剂型设计、处方组成及制备、质量控制 混悬剂:助悬剂的选择、稳定性、流动性 乳剂:粘度(处方组成) 软膏剂:附着性、铺展性、粘度. 内 容 提 要. 药物制剂的设计基础 药物制剂处方前的研究工作(包括有关药物的文献检索,药物的物理化学性质测定以及药物制剂的优化设计)。重点讲述药物的 多晶型、药物的分配系数。 介绍药物的分析方法与药物的配伍及相容性。 制剂处方的优化设计. 第一节 概 述. 新药研究与开发的起点:剂型设计 依据

Download Presentation

第十五章 药物制剂的设计

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


5789335


5789335


5789335


5789335

  • 1. 2. 3.


5789335

  • 1.

  • 2.

  • 3.


5789335


5789335

1.


5789335

2.


5789335

3.


5789335

4.

5.


5789335

1

2

3

4

,


5789335

  • 1.

  • 2.


5789335

  • >60%

  • 30%<< 60%:

  • 30%< < 1%2%


5789335

1


5789335

2

  • :

  • B


5789335

3

4


5789335

5


5789335


5789335

1.

  • 2.

    10~20


5789335

3.


5789335

>>>

  • 1.

  • pH


5789335


5789335

2.

  • 3.


5789335

1.

2.


5789335

  • (0.5m ~5m)


5789335

1.

2.


5789335


5789335

  • CmaxtmaxkakeVdMRTAUC


5789335

  • tmaxCmaxAUC


5789335


5789335


5789335

1. IPA

(ASHP)1970750


5789335

2. Drug &pharmacology

  • ElsevierEMBASE

3. MEDLINE

  • MEDLARS 4000


5789335

4.

900

198950008001994

5.


5789335

1. RxList - The Internet Drug Index (http://www.rxlist.com)

RxListInternet4000

(1)


5789335

Keyword SearchSearch forSearch

(RxList-ID)

RxList-IDClick to Identify Imprint Code


5789335

(2)The Top200

200 979695The Top200 97200Brand NameManufacturerGeneral NameGeneral Name


5789335

2.PharmacokineticsPharmacodynamics and Biopharmaceutics homepage

http://griffin.vcu.edu/gkrishna/PK/pk.html

1Drug Metabolism Cytochrome P450s

2PK/PD Resources PKPD

3PK Equations PK Equations PK Solutions2.0


5789335

pKa


5789335

(o)(O)(w)(w)

  • (partition coefficients)

a(o) a(w)


5789335

C(o) ,C(w)


5789335


5 2000 r min 10

52000r/min10


5789335

  • P1:11:41:9

  • HPLC


5789335

()

1

()()


5789335

*2.

X

  • 30


5789335

1

  • Amp91~92Bmp87~88mp87~88


5789335

  • 1

  • 25~50II175I200


5789335

2

  • 86II97


5789335

  • DTADSCDTA

  • (DSC) DTA


5789335

  • dQ/dtDSC

  • DSC

    170.5


5789335

DSC

  • 358K(B)

  • 363K(A)358K


5789335

3

  • ()

  • ()1690 cm-1~1730cm-1(N-H)3330 cm-1~3400cm-1


5789335

(Nujol)

4X

X


5789335

  • 3.

    1

  • 200

  • 180


5789335

2

() () pH(CPP)


5789335


5789335

  • 300MPaAB20%


5789335

4.

1

-5-32120%4%1.4


5789335

2

-5-II


5789335

GB

3

() >>


5789335

()

()


5789335

()

()


5789335

:()


5789335

1.

  • 190nm~390nm


5789335


5789335

2.


5789335

3.

(ng)HPLC

4.


5789335

()

(TLC)


5789335

1205540DSCDTATLCHPLC

2552


5789335

1pH


5789335

2

3

4


5789335


5789335


5789335

(simplex optimization method)

  • nn+1


5789335

  • j


5789335

  • R(B)R(W)E


5789335


5789335


5789335

1


5789335

  • (orthogonal experiment design)


5789335

2(uniform design)


5789335

3


5789335

4central composite design)

  • 5

  • 12k2k1/2

    2

    3


5789335

  • 1985

  • 2002SFDA


5789335


5789335

  • 16234

    45 6


5789335

1

2

3

4

5

6

7

8

9


5789335


5789335

  • 32 123456


5789335

  • 789101112131415


5789335

  • 161718192021 22


5789335

  • 2324252627

  • 2829303132


5789335

  • 33


  • Login