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Featured Article :. Severe Hypoglycemia and Mortality After Cardiovascular Events for Type 1 Diabetic Patients in Sweden. Tom W.C. Lung, Dennis Petrie, William H. Herman, Andrew J. Palmer, Ann-Marie Svensson, Bjorn Eliasson, and Philip M. Clarke. Diabetes Care Volume 37: 2974-2981

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Featured article

Featured Article:

Severe Hypoglycemia and Mortality After Cardiovascular Events for Type 1 Diabetic Patients in Sweden

Tom W.C. Lung, Dennis Petrie, William H. Herman, Andrew J. Palmer,

Ann-Marie Svensson, Bjorn Eliasson, and Philip M. Clarke

Diabetes Care

Volume 37: 2974-2981

November, 2014


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STUDY OBJECTIVE

  • To examine whether previous severe hypoglycemic events were associated with the risk of all-cause mortality after major cardiovascular events in type 1 patients

Lung T. W.C. et al. Diabetes Care 2014;37:2974-2981


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STUDY DESIGN AND METHODS

  • Data were from the Swedish National Diabetes Register

  • Patients included those with type 1 diabetes who visited a clinic during 2002–2010 and experienced a major cardiovascular complication after the visit

  • Two-part model was estimated for all-cause mortality after a cardiovascular event:

    1.Logistic regression for death within the first month

    2.Cox proportional hazards model conditional on 1-month survival

  • 5-year cumulative mortality risk was estimated from the models for patients with and without prior diabetes complications

Lung T. W.C. et al. Diabetes Care 2014;37:2974-2981


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RESULTS

  • 1,839 patients experienced major cardiovascular events

  • 403 had previously experienced severe hypoglycemic events

  • 703 died within our study period

  • A prior hypoglycemic event was associated with a significant increase in mortality after a cardiovascular event

  • Patients with prior hypoglycemia had an estimated 5-year cumulative mortality risk of 52.4 and 39.8% for myocardial infarction and stroke, respectively

Lung T. W.C. et al. Diabetes Care 2014;37:2974-2981


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Lung T. W.C. et al. Diabetes Care 2014;37:2974-2981


Featured article

Lung T. W.C. et al. Diabetes Care 2014;37:2974-2981


Featured article

Lung T. W.C. et al. Diabetes Care 2014;37:2974-2981


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CONCLUSIONS

  • Patients with type 1 diabetes in Sweden with prior severe hypoglycemic events have increased risk of mortality after a cardiovascular event

Lung T. W.C. et al. Diabetes Care 2014;37:2974-2981


Featured article

Lung T. W.C. et al. Diabetes Care 2014;37:2974-2981


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