1 / 1

COMPARATIVE STUDY OF AMOXICILLIN TRIHYDRATE MICROSPHERES USING SYNTHETIC AND SEMI-SYNTHETIC POLYMERS

COMPARATIVE STUDY OF AMOXICILLIN TRIHYDRATE MICROSPHERES USING SYNTHETIC AND SEMI-SYNTHETIC POLYMERS. Subhasis Kundu , Asim Sattwa Mandal , Ketousetuo Kuotsu Department of Pharmaceutical Technology, Jadavpur University, Kolkata-32, India. E-mail: subhasis_ceutics@yahoo.co.in.

blaine
Download Presentation

COMPARATIVE STUDY OF AMOXICILLIN TRIHYDRATE MICROSPHERES USING SYNTHETIC AND SEMI-SYNTHETIC POLYMERS

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. COMPARATIVE STUDY OF AMOXICILLIN TRIHYDRATE MICROSPHERES USING SYNTHETIC AND SEMI-SYNTHETIC POLYMERS SubhasisKundu, AsimSattwaMandal, Ketousetuo Kuotsu Department of Pharmaceutical Technology, Jadavpur University, Kolkata-32, India. E-mail: subhasis_ceutics@yahoo.co.in Purpose: The aim of the study was to prepare Amoxicillin trihydrate microspheres with semi-synthetic and synthetic polymers for comparative evaluation of swelling factor, entrapment efficacy and in vitro release performances. Materials and Methods:Microspheres were prepared using Amoxicillin trihydrate as a model drug, Sodium carboxy methyl cellulose (NaCMC) as semi-synthetic polymer, Carbopol 940 as synthetic polymer, fused Calcium chloride and Na-alginate by inotropicgelation method. Chemical reaction between matrix forming Na-alginate polymer and divalent cation salt like Calcium chloride was utilized for development of microspheres.λmaxof Amoxicillin trihydrate was measured at pH 1.2 by JASCO V-550 double beam UV/Vis spectrophotometer. Calibration curve was prepared using above medium. Swelling study, entrapment efficacy and in vitro release study have been performed for optimization of microspheres. Fig-3:Swelling factor of the Microspheres Fig-4:In-vitro release profile of Amoxicillin microspheres in pH-1.2 (acidic buffer) Fig-1:Carbopol 940 microsphere Fig-1:Na CMC microsphere Conclusion:Sodium CMC blended microsphere is better formulation for controlled release of Amoxicillin trihydrate than Carbopol 940 with respect to swelling study, entrapment efficacy and in vitro release study. Result:Swelling factors of different formulations containing NaCMC and Carbopol 940 were 52.5% and 16.0%. Drug entrapment efficacy is also greater in case of NaCMC microsphere (55.67%) than Carbopol 940 (49.52%) respectively. Microspheres prepared with both polymers were able to release the drug constantly for 8 hr study. Sodium CMC and Carbopol 940 blended polymer showed 86.28% and 81.59% release respectively. Acknowledgements:This work was supported by contingency grant from UGC-MHRD, Govt. of India. National Seminar 2011 on Biotechnology in Pharmaceutical Sciences: Recent Avenues on3rd December, 2011 at Dr. H. L. Roy Building, Jadavpur University, Kolkata – 700032.

More Related