Hyperbilirubinemia

Hyperbilirubinemia PowerPoint PPT Presentation


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Introduction:. Newborns appear jaundiced when bilirubin level > 7 mg/dL while adults appear jaundiced when bilirubin level > 2 mg/dL.25-50% of all term newborns develop clinical jaundice.6% of term newborns have maximum bilirubin level >12.9 mg/dL.3% > 15mg/dL.Normal Newborn produces 6-10 mg/ k

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Hyperbilirubinemia

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1. Hyperbilirubinemia Moderator: Dr.A.Abo Al-Rub Presented by: Dr.M.Mesmeh

2. Introduction: Newborns appear jaundiced when bilirubin level > 7 mg/dL while adults appear jaundiced when bilirubin level > 2 mg/dL. 25-50% of all term newborns develop clinical jaundice. 6% of term newborns have maximum bilirubin level >12.9 mg/dL. 3% > 15mg/dL. Normal Newborn produces 6-10 mg/ kg/day bilirubin.

3. Types of bilirubin: Unconjugated bilirubin tightly bound to albumin. Free bilirubin. Conjugated bilirubin. Delta fraction.

4. Source of bilirubin: Heme containing proteins: 75% RBCs Hb: 1g Hb - 34mg bilirubin. Accelerated Hb release from from RBCs: a) Isoimmunization. b) RBCs biochemical abnormalities. c) Abnormal RBCs morphology. d) Sequestered RBCs. c) Polycythemia.

5. 2. 25% early labeled bilirubin. a) Inefective erythropoiesis. b) Other heme containing protiens. c) Free heme.

6. Bilirubin metabolism: Heme ring oxygenase bilivirdin reductase CO+iron UCB+albumin UCB+ligandin UCB+ligandin UDPG-T against gradient Biliary tract CB(mono,di-)

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