Introduction:. Newborns appear jaundiced when bilirubin level > 7 mg/dL while adults appear jaundiced when bilirubin level > 2 mg/dL.25-50% of all term newborns develop clinical jaundice.6% of term newborns have maximum bilirubin level >12.9 mg/dL.3% > 15mg/dL.Normal Newborn produces 6-10 mg/ k
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1. Hyperbilirubinemia Moderator: Dr.A.Abo Al-Rub Presented by: Dr.M.Mesmeh
2. Introduction: Newborns appear jaundiced when bilirubin level > 7 mg/dL while adults appear jaundiced when bilirubin level > 2 mg/dL.
25-50% of all term newborns develop clinical jaundice.
6% of term newborns have maximum bilirubin level >12.9 mg/dL.
3% > 15mg/dL.
Normal Newborn produces 6-10 mg/ kg/day bilirubin.
3. Types of bilirubin: Unconjugated bilirubin tightly bound to albumin.
4. Source of bilirubin: Heme containing proteins:
75% RBCs Hb: 1g Hb - 34mg bilirubin.
Accelerated Hb release from from RBCs:
b) RBCs biochemical abnormalities.
c) Abnormal RBCs morphology.
d) Sequestered RBCs.
5. 2. 25% early labeled bilirubin.
a) Inefective erythropoiesis.
b) Other heme containing protiens.
c) Free heme.
6. Bilirubin metabolism: Heme ring oxygenase bilivirdin reductase CO+iron UCB+albumin UCB+ligandin UCB+ligandin UDPG-T against gradient Biliary tract CB(mono,di-)