Antibiotics: Principles and Illustrative Cases. Jake Nania, M.D. Pediatric Infectious Diseases February 2, 2006. Making wise antibiotic choices. #1 Know what you’re targeting! Send appropriate diagnostic studies before antibiotics are started
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Jake Nania, M.D.
Pediatric Infectious Diseases
February 2, 2006
#1 Know what you’re targeting!
#2 Pathogen-specific factors
Know (or look up) susceptibility patterns for suspected organisms:
Know agents likely active against bacteria for which susceptibilities are not usually done
Most studies show no effect
The timing was suboptimal. Clear benefit when given in the 30 minutes BEFORE incision
Not supported by available data
Initial Rx based on likely pathogen & how ill
Infectious Diseases, 6th ed.,2005 Churchill Livingstone
Chapter 16 - Principles of Anti-infective Therapy
Update of Practice Guidelines for the Management of Community-Acquired
Pneumonia in Immunocompetent Adults
Lionel A. Mandell,1 John G. Bartlett,2 Scott F. Dowell,3
Thomas M. File, Jr.,4 Daniel M. Musher,5 and Cynthia Whitney3,a
As Antibiotic Discovery Stagnates ...
A Public Health Crisis Brews
BAD BUGS, NO DRUGS