Scopolamine
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Scopolamine. Julia Bedell Laci Click Meredith Barr. Where does it come from?. Scopolamine is an alkaloid drug found as a secondary metabolite of plants in the Solanaceae family. Solanaceae s are nightshade plants

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Presentation Transcript
Scopolamine l.jpg

Scopolamine

Julia Bedell

Laci Click

Meredith Barr


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Where does it come from?

  • Scopolamine is an alkaloid drug found as a secondary metabolite of plants in the Solanaceae family.

    • Solanaceaes are nightshade plants

    • Examples of plants in the family that produce scopolamine are henbane and jimson weed

  • Jimson Weed


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Chemical make up

  • Alkaloid drugs

    • In the tropane group

    • Alkaloid drugs are defined as naturally occurring amines that are produced by a plant

    • Many have anesthetic or analgesic effects

  • Chemical formula

    • C17H21NO4


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A drug with a sorted history!

  • Project MKULTRA

    • In the 1950’s the CIA investigated the use of Scopolamine as a “truth serum”

    • Due to hallucinogenic side effects the drug was determined to be an unreliable interrogation drug


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So what do we use it for?

  • Scopolamine is used as an anti-nausea medication

  • It is given in patch (transdermal) form to treat nausea associated with motion sickness and chemotherapy.

  • Marketed as Scopoderm and Transderm-V


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Mechanism of Action

  • Scopolamine is an antagonist at muscarinic acetylcholine receptors (M1)

  • Blocking acetylcholine from binding to the receptor blocks Acetylcholine mediated nerve impulses from traveling through the body


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Mechanism of Action

  • In motion sickness a person feels ill because of conflicting sensory information from the visual senses and balance center in the inner ear.

  • To treat motion sickness this antagonist blocks the acetylcholine mediated nerve impulses to the inner ear where balance is controlled.


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Other Medical Uses

Scopolamine is sometimes used for other medical purposes such as:

At one point, Scopolamine was mixed with morphine to produce a state known as “twilight sleep”.

“Twilight sleep” was induced to yield an insensibility to pain without loss of consciousness

  • CNS depressant for pain management

  • Pupil Dilator

  • Paralysis of eye muscles

  • Antispasmodic


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The negative side of Scopolamine use

  • Acetylcholine is the major neurotransmitter found in autonomic ganglia, and is the chemical that allows neurons to communicate for sensory input and muscle control.

  • Muscarinic receptors are important for control of:

    • Central Nervous System

    • Parasympathetic control of heart, lungs, and gastrointestinal functioning


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Negative side of Scopolamine cont’

  • By blocking Ach- M1 functioning, you could inhibit the Central and Peripheral Nervous System functioning.

  • Acetylcholine antagonists also cause heart rate to increase which can lead to myocardial infarction or angina.


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Remember!

  • This drug is highly toxic!

  • It must be used in small doses.

  • An overdose of Scopolamine can cause delirium, paralysis, stupor, heart failure, and death.


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Other Side Effects

  • Dry mouth

  • Blurred vision

  • Constipation

  • Drowsiness

  • Poor Memory

  • Unequal dilation of pupils (also known as anisocoria)

Anisocoria


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Negative uses of Scopolamine

  • In recent years the use of Scopolamine for criminal purposes has increased dramatically.

  • Scopolamine is often used as a date rape drug because it causes delirium, hallucinations, and has sedative effects on the victim.


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For more information

  • http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682509.html

  • http://www.drugs.com/mtm/scopolamine.html

  • http://en.wikipedia.org/wiki/Scopolamine

  • http://www.transdermscop.com/ (commercial site)

  • http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1641616