In Case You Get Bored: Propose Reasonable Mechanisms. Hydrozirconation/Zr → Zn Transmetalation/Aldimine Addition: One-pot Synthesis of Allylic, C -Cyclopropyl and Homoallylic Amines from Alkynes. “The time is apt for synthetic chemists to fully enter the world of organozirconium … chemistry.”
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Hydrozirconation/Zr→Zn Transmetalation/Aldimine Addition:
One-pot Synthesis of Allylic, C-Cyclopropyl
and Homoallylic Amines from Alkynes.
“The time is apt for synthetic chemists to fully enter the world of organozirconium … chemistry.”
V. Snieckus in Titanium and Zirconium in Organic Synthesis, I. Marek, Ed., Wiley-VCH, Germany, 2002.
Christopher Kendall and Prof. Peter Wipf
Dept. of Chemistry, University of Pittsburgh
Pittsburgh, PA 15260
Enabling Methodology: Zr→Zn Transmetalation, Aldehyde Addition
Enabling Methodology: Et2Zn Addition to Benzaldimines
Zr→Zn Transmetalation, Aldimine Addition: Optimization
Zr→Zn Transmetalation, Aldimine Addition:
Zr→Zn Transmetalation, Enantioselective Aldimine Addition
Zr→Zn Transmetalation, Aldiminium Addition
Zr→Zn Transmetalation, Diastereoselective Aldimine Addition
Wipf Group Synthetic Applications
Discovery and Scope
Relative Stereochemistry and Mechanism
Transition-Metal-Mediated Cascade Reactions: C,C-Dicyclopropylmethylamines
By Way of Double C,C-s-Bond Insertion into Bicyclobutanes