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H ybrid F luorescence M olecular T omography - X -ray C omputed T omography method and system

H ybrid F luorescence M olecular T omography - X -ray C omputed T omography method and system. Project Overview and Updates Deliverables & Milestones. Veronika Erben. Project Overview. Titel: Hybrid F luorescence M olecular T omography -

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H ybrid F luorescence M olecular T omography - X -ray C omputed T omography method and system

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  1. HybridFluorescence MolecularTomography-X-rayComputed Tomographymethod and system • Project Overview and Updates • Deliverables & Milestones Veronika Erben

  2. Project Overview • Titel: Hybrid Fluorescence Molecular Tomography - • X-ray Computed Tomography method and system • Acronym: FMT-XCT • Coordinator: Vasilis Ntziachristos (HMGU/TUM) • Duration: March 01,2008 – February 28, 2012 • Funding: European Commission- FP7, € 4.5 Mio • http://www.fmt-xct.eu/ • Members only: Annex 1, Presentations, Reports … • Username: fmt-xct • Password: eu_proj_2008 • Platform for data exchange • Upload/download of files at: http://www.fmt-xct.eu/transfer/ • User: fmt-xcttransfer, Login: get4data

  3. Partners FMT-XCT

  4. Reporting Schedule4 Year Collaborative Project with 4 Reporting Periods Reporting:Financial & Activity report Report 1 accepted without any recommendations Report 2 will be reviewed Report Half time report Report Final report ReportingPeriod 1 ReportingPeriod 2 ReportingPeriod 3 ReportingPeriod 4 +60 days Start 12 months 12 months 12 months 12 months February 2009 February 2012 February 2011 March 01,2008 February 2010

  5. Every partner can register Upload of all documents by HMGU Reporting Schedule4 Year Collaborative Project with 4 Reporting Periods New online tool New online tool for reporting - ECAS

  6. Reporting Schedule4 Year Collaborative Project with 4 Reporting Periods Finances 1.579.000€ Prefinancing 1+2 + 557.000€ First interim payment (spent Year 1) 2.136.000€ (~ 50% of budget) received from EC (not spent) EC pays up to 85% of the total budget (~ 3.8 m) 15% will be paid after acceptance of the final report (~700 k)

  7. Reporting Schedule4 Year Collaborative Project with 4 Reporting Periods Work packages MANAGEMENT (Wp1) WP leader: HMGU IN-VIVO ALGORITHMIC TRAINING & PRE-CLINICAL IMAGING TECHNICAL DEVELOPMENT XCT Development (Wp2) WP leader: CEA-Leti Cancer imaging with focus on breast cancer imaging (Wp6) WP leader CEA-Lime FMT-XCT integration (Wp5) WP leader: HMGU Theory for 360 degree FMT (Wp3) WP leader: FORTH Imaging Cancer Therapy for enabling intervention (Wp7) WP leader: UZH FMT Inversion with priors (Wp4) WP leader: UCL FMT-XCT Imaging accurancy vs PET-XCT (Wp8) WP leader: FIHGM TRAINING, DISSEMINATION &TECHNOLOGY TRANSFER (Wp9) WP leader: HMGU

  8. Reporting Schedule4 Year Collaborative Project with 4 Reporting Periods Animal models Information for extension of Helmholtz animal protocols Ifavailable, please attach or cite already published literature of comparable studies 1.1 Background 1.2 Description of the animal model Name, strain Origin Preparation In case of genetic modification, please also state whether this may result in any distress for the animal (in case yes, to which degree): 1.3 Imaging region 1.4 Imaging probes (name; established/clinically approved; references) 1.5 Injection 1.6 Purpose 1.7 Number of experimental groups 1. Control untreated; 2. Contrast agent 1; 3. Contrast agent 2; 1.8 Reference number of comparable foreign animal protocol (submission to): Animal models should be integrated in animal protocols!

  9. Deliverables & Milestones Deliverables • Deliverables and milestones: once a year with report • Year 1 (March 08- February 09): Report 1 • Year 2 (March 09- February 10): Report 2, April 6, 2010 • If not achieved please explain!

  10. WP1 Management - WP leader HMGU Year 1 (March 08 – Febr 09) Report 1 Milestone 1: Consortium Agreement March `08 Year 2 (March 09 - Febr 10) Report 2 Year 3 (March 10 - Febr 11) Report 3

  11. WP2 XCT Development WP Leader CEA-LETI Year 1 (March 08 - Febr 09) Report 1 Year 2 (March 09 - Febr 10) Report 2 Milestone No 5 (mo 18= August 09):XCT dual energy vs. contrast enhancement

  12. WP3 Theory for 360 degree FMTWP leader Forth Year 1 (March 08 – Febr 09) Report 1 * New Deliverable „Ultra- fast Inversion for FMT“  month 24=Feb. 10 Year 2 (March 09 - Febr 10) Report 2 Milestone No. 4 (month 15 = May 09): Direct vs Conventional FMT performance Year 3 (March 10 - Febr 11) Report 3

  13. WP4: FMT inversion with image priors WP leader: UCL Year 1 (March 08 – Febr 09) Report 1 Year 2 (March 09 - Febr 10) Report 2 • Milestone No 6 (month 21 = Nov 09): Optimal FMT inversion with priors Year 3 (March 10 - Febr 11) Report 3

  14. WP5: FMT –XCT integration WP leader: HMGU Year 1 Milestone No 8 (mo 24 = Feb. `10) : FMT-XCT Shielding Year2 Year 3

  15. WP6: Cancer imaging with focus on breast cancer WP Leader: CEA Lime Year 1 Year2 Lime i Milestone No10: FMT-XCT methodology for in-vivo quantification Oct. 2010 Year 3

  16. WP7: Imaging cancer therapy for enabling intervention WP leader: UZH Year 1 Year2 i Milestone No 11: FMT-XCT methodology for quantified treatment imaging Feb. `11 Year 3

  17. WP8: FMT-XCT imaging accuracy vs. PET-XCT WP leader: FIHGM Year 1 Year2 Year 3 i

  18. WP9: Training & Dissemination WP leader: HMGU , Year2 • 2 Training sessions: • Cea- Leti, Grenoble, 6th and 7th of July 2009: Advanced X-rays imaging techniques • 2) UCL, London, 16-18 September 2009, Reconstruction methods i Year 3 Next training session: Cea-Lime & UZH on animal models/cancer imaging October 2010

  19. Print outs available

  20. Thank you for your attention! Danke für Ihre Aufmerksamkeit! Ευχαριστώ πολύ για την προσοχή σας! Merci de votre attention ! Gracias por su atención !

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