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Kuo, Soong-Yu

Kuo, Soong-Yu. IUFRO Division 5 Conference 5.07B Using Plantation And Small-Diameter Timber In Composites. Soong-Yu Kuo 1 , Wen-Li Lo 1 , Chung-Yi Chen 1 , Jin-Cherng Huang 2 and Hsien-Toung Huang 2. Chemical and Cytotoxic Constituents from the Leaves of Cinnamomum subavenium.

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Kuo, Soong-Yu

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  1. Kuo, Soong-Yu IUFRO Division 5 Conference 5.07B Using Plantation And Small-Diameter Timber In Composites

  2. Soong-Yu Kuo1, Wen-Li Lo1, Chung-Yi Chen1, Jin-Cherng Huang2 and Hsien-Toung Huang2 Chemical and Cytotoxic Constituents from the Leaves of Cinnamomum subavenium 1Basic Medical Science Education Center, Fooyin University; Kaohsiung County 83101, Taiwan (R.O.C.); 2Department of Forest Products Science, National Chia-Yi university, Chiayi, Taiwan (R.O.C.)

  3. Aim of Work And Methods • Motive：The chemical constituents and the biological activity of the leaves of Cinnamomum subavenium Miq. (Lauraceae) have not yet been reported. • Purpose：To elucidate the cytotoxic mechanism of subamolides (1 and 2), the capacity of subamolide D (1) and subamolide E (2) to inhibit cell cycle phase distribution. • Method：Propidium iodide staining and cytometry analysis were used to evaluate the cell cycle progression of the treated SW480 cells.

  4. Results • The marked increase in sub-G1 apoptotic fraction appeared in cells treated with 25-100 μM subamolide D (1) or subamolide E (2) in a concentration-dependent manner. • Additionally, incubation with 25, 50 and 75 μM subamolide D (1) for 24 h resulted in the accumulation of cells in G2/M phase (25.4, 29.8 and 23.0 %, respectively) compared with that in control (15.4 %). • When cells were treated with 100 μM subamolide D (1) or subamolide E (2), > 25 %, > 78 %, and > 85 % sub-G1 fraction was noted for treated cells after 8 h, 16 h, and 24 h exposure, respectively.

  5. Conclusion • Subamolides D (1) and E (2) caused DNA damage in a dose- and time-dependent manners. • These findings suggest that compounds present in C. subavenium Miq. (e.g. subamolides D (1) and E (2)) may have chemopreventive properties. • This study is the first to investigate the effect of subamolides D (1) and E (2) on cell cycle phase distribution in human colorectal cancer cells.

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