LACTAL vaginal gel

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LACTAL vaginal gel

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2. CTS Pharmaceutical Laboratories are presenting : Femina

3. A New Dimension in Feminine Hygiene Line features: 4 types of specially formulated external vaginal cleansing products Soothing application gel gently soothes irritated external vaginal areas A lubricating gel for vaginal dryness Intimate wipes

4. Many women suffer from vaginal discharge, often associated with a disturbance of the normal vaginal environment, including a change in the vagina's normal level of acidity The normal pH of the vagina is acidic, fluctuating between 3.8 – 4.5, discouraging infection from occurring The acidic environment is created by the presence of Lactic acid, which is the byproduct of the glycogen metabolism by normal - existing bacteria

5. Mechanism of Vaginal Defense

8. Symptoms of vaginal imbalance Vaginal tenderness Itching Unpleasant vaginal discharges Redness Dryness Pain during intercourse

9. Why choose Femina? 4 Good reasons: The Company behind the product Line performance Line advantages Products quality

10. Why choose Femina? CTS Pharmaceutical When you marry someone , you better know it’s family…

11. Why choose Femina? CTS Pharmaceutical Pharmaceutical Company Femina line is manufactured by a leading Israeli pharmaceutical company operating since 1921. Focus on the Gynecology Field- CTS Develops, manufacture and market pharmaceutical products ,among them is a wide range of pharmaceutical gynecological products. Femina line was developed 14 years ago as a completion to our gynecological pharmaceutical and medical device products and was initially introduced only to Gynecologists. International experience CTS enjoy business associations with some of the major world companies, amongst them: Astellas, UCB, Nycomed, Besines, Sanofi-Aventis, Mitsubishi Pharma, OPI and others.

12. Why choose Femina? Line preformance No 1 brand in Israel Femina is the leading line in Israel for intimate wash, before Liginia, care-free The most recommended brand by Gynecologists in Israel 48% of the gynecologists in Israel, that recommends on intimate wash, recommends on Femina. Femina market share in the intimate wash Category – 42% !!. International Market penetration Since Last year (2008) : 7 distribution contracts for international markets. (USA/Canada, Australia, Singapore, Taiwan, Romania , S. Africa, Cyprus)

14. Why choose Femina? Line Advantages Comprehensive solution for women intimate wash needs : Contains 7 preparations covering women needs in all aspects: All ages Different time’s in woman life.( pregnancy, period , menopausal) Daily use and special use ( usual day routine , traveling , intercourse, irritation.. etc Friendly Formulation: Free of Parabens Free of SLS & SLES

15. Why choose Femina? Line Advantages 3.5 PH level formulation Help maintain acidic pH; contains lactic acid combined with its special formulation developed for specific women’s needs encourage the natural vaginal acidity & promote the body's natural microbial balance Calm the vaginal discharge symptoms; Help women to avoid reappearance of vaginal discharge “Live” Brand : Due to the fact it is a strategic field of CTS , the line is covered by continues R&D support and marketing support by its brand managers Future developments under evaluation: ECOCERT formulations , Teenage version, intimate deodorant, calming cream for the intimate area.

16. Femina liquid soaps contains Lactic Acid Lactic Acid: Restores the vaginal pH to normal values (4,5) Help the growth of natural flora Decrease the number of pathological microorganism Long lasting antibacterial action, as it maintains the natural flora and normal pH

17. Femina The leading intimate wash brand in Israel

19. Scientifically formulated to promote the body's natural vaginal balance Contains Lactic Acid to promote the natural vaginal acidic pH balance 3.5 PH level formulation Contains Tree Tea Oil, one of natures essential oils well known for its natural mild antiseptic properties which helps promote the body's natural microbial balance Cleansing and refreshing Suitable for women of all ages For daily use Free of Parabens Free of SLS & SLES Hypo-Allergenic

20. What is Tea Tree Oil? Botanical Name: Melaleuca Alternifolia Tea tree has a long history of traditional use: Australian aboriginals used tea tree leaves for healing skin cuts, burns, and infections by crushing the leaves and applying them to the affected area Tea tree oil contains constituents called terpenoids, which have been found to have antiseptic and antifungal activity.

21. Use of tea-tree oil in Trichomonal Vaginitis In June 1962 an American report was published in obstetrics and Gynecology on the use of tea-tree oil in trichomonal vaginitis. The study comprised 130 women, including ninety-six cases of trichomonal vaginitis, and also several cases of thrush and cervicitis. As controls the author treated fifty other cases with standard antitrichomonal suppositories.

22. Tea-tree oil & Candida Albicans For this study tea-tree oil was made into pessaries for insertion into the vagina once every night. After thirty days the twenty-seven patients were examined, and twenty-three showed a complete cure with no further discharge or burning. The other four showed a moderate improvement.

23. Antimicrobial Activity This review summarizes recent developments of the antimicrobial and anti-inflammatory activities of the oil and its components, as well as clinical efficacy.

24. Antifungal activity Studies conclusions: The majority of the organisms were sensitive to the essential oil, with TTO (Tea Tree Oil) and terpinen-4-olo being the most active oils showing antifungal activity at minimum inhibitory concentration values lower than other drugs. SIGNIFICANCE AND IMPACT OF THE STUDY: This study provides a sample large enough to determine the antifungal properties of TTO and terpinen-4-olo and suggests further studies for a possible therapeutic use.

26. Enriched with Sea Buckthorn oil, which is well known for its soothing and healing components to prevent over drying and irritation For women of all ages 3.5 PH level formulation For daily use Free of Parabens Free of SLS & SLES

27. Sea Buckthorn Sea buckthorn contains different kinds of nutrients and bioactive substances such as vitamins, carotenoids, flavonoids, polyunsaturated fatty acids, free amino acids The clinical trials and scientific studies during the 20th century confirmed the medicinal values of sea buckthorn.

29. Urogenital Mucous and Sea Buckthorn

32. Enriched with a Vitamin B3 moisturizer to help prevent vaginal dryness and irritation Specially recommended for women suffering from vaginal dryness and for menopausal women 3.5 PH level formulation For daily use Free of Parabens Free of SLS & SLES Hypo-Allergenic

33. Moisturizing & Anti Inflammatory effect of vitamin B3 Other names include: 3-pyridinecarboxamide, Nicamid, Nicotinamide, Nicosedine, Nicotinic Acid Amide, Nicotylamidum, and Vitamin PP Niacinamide has been used in skin care products, including moisturizers, anti-aging products Niacinamide has demonstrated anti-inflammatory actions which may be of benefit in patients with inflammatory skin conditions.

34. Supportive literature Measuring the effects of topical moisturizers on changes in stratum corneum thickness, water gradients and hydration in vivo Crowther JM. Br J Dermatol. 2008 Sep;159(3):567-77. Epub 2008 Jul 4 Nicotinamide - biologic actions of an emerging cosmetic ingredient Otte N. Int J Cosmet Sci. 2005 Oct;27(5):255-61 Nicotinic acid/niacinamide and the skin Gehring W. J Cosmet Dermatol. 2004 Apr;3(2):88-93.

36. Enriched with Aloe Vera – well known for its soothing, moisturizing and cooling properties for relieving skin discomfort Recommended for use during pregnancy, after childbirth, during menstruation (vaginal sensitivity), and after swimming in pool/sea etc. 3.5 PH level formulation For daily use Free of Parabens Free of SLS & SLES Hypo-Allergenic Sensitivity test approved

37. Antimicrobial, Antifungal & Healing activities of Aloe A novel polyherbal microbicide with inhibitory effect on bacterial, fungal and viral genital pathogens “…It has pronounced inhibitory action against Candida glabrata, Candida albicans and Candida tropicalis isolated from women with vulvovaginal candidiasis, including three isolates resistant to azole drugs and amphotericin B…”

38. Antimicrobial, Antifungal & Healing activities of Aloe Aloe vera: a systematic review of its clinical ffectiveness “…Topical application of aloe vera is not an effective preventative for radiation-induced injuries. It might be effective for genital herpes and psoriasis... ”

39. Antimicrobial, Antifungal & Healing activities of Aloe Wound healing. Oral and topical activity of Aloe vera “…The influence of Aloe vera, orally and topically, on wound healing was studied…These data suggest that A. vera is effective by both oral and topical routes of administration…”

41. Specially formulated and enriched with a high concentration of natural soothing plant extracts such as Aloe Barbadensis Leaf Extract, Allantoin, Echinacea Angustifolia, Calendula Officinalis Extract, Comfrey Extract, Propolis Extract, Witch Hazel Extract and Matricaria Extract (Chamomile) Relieves itching, burning, soreness, unpleasant odor and other irritations of the external vaginal area The use of this preparation is not a replacement for medical treatment

42. Natural healing extracts - Comfrey What is Comfrey? Comfrey (Symphytum officinale L.) is a perennial herb of the family Boraginaceae Beneficial effects of Comfrey as an active ingredient: The herb contains allantoin, a cell proliferant that speeds up the natural replacement of body cells. Comfrey is used to treat severe burns, acne and other skin conditions.

43. Natural healing extracts - Allantoin What is Allantoin? Major metabolic intermediate. Beneficial effects for Allantoin a moisturizing and keratolytic effect, increasing the water content of the extracellular matrix and enhancing the desquamation of upper layers of dead skin cells Increasing the smoothness of the skin Promotion of cell proliferation and wound healing Soothing, anti-irritant, and skin protectant effect by forming complexes with irritant and sensitizing agents

44. Natural healing extracts - Coneflower (Echinacea Angustifolia) What is Coneflower (Echinacea Angustifolia)? Echinacea is a genus of nine species of herbaceous plants in the family Asteraceae commonly called Coneflower. Beneficial effects for Coneflower as an active ingredient: Echinacea is found as immuno-stimulator, stimulating the body's non-specific immune system and warding off infections Efficient to treat Vaginal yeast infections

45. Natural healing extracts - Propolis What is Propolis? Propolis is a resinous mixture that honey bees collect from tree buds, sap flows, or other botanical sources. Beneficial effects for Propolis as an active ingredient: Propolis show powerful local antibiotic and antifungal properties Effective as alternative treatment for chronic vaginal infection (Vaginitis)

46. Natural healing extracts - Witch-hazel (Hamamelis) What is Witch Hazel? The main constituents of the extract include gallic acid, catechins, proanthocyanins, flavonoids, essential oil, choline, saponins, and bitters. Witch hazel hydrosol is used in skin care Beneficial effects for Witch hazel as an active ingredient: Witch hazel leaf has been used for minor injuries of the skin, inflammation of the skin and mucous membranes

47. Natural healing extracts - Matricaria (Chamomile) What is Matricaria? The flowers of chamomile provide 1-2% volatile oils containing alpha-bisabolol, alpha-bisabolol oxides A & B, and matricin (usually converted to chamazulene).  Other active constituents include the bioflavonoids apigenin, luteolin, and quercetin. Beneficial effects for Matricaria as an active ingredient: Chamomile has anti-inflammatory, antioxidant and antimicrobial activities Wound healing

48. Natural healing extracts - Calendula Officinalis What is Calendula Officinalis? It was used in ancient Greek, Roman, Arabic and Indian cultures as a medicinal herb The petals and pollen contain triterpenoid esters (an anti-inflammatory) and the carotenoids flavoxanthin and auroxanthin (antioxidants, and the source of the yellow-orange coloration). The leaves and stems contain other carotenoids, mostly lutein (80%) and zeaxanthin (5%), and beta-carotene. Plant extracts are also widely used by cosmetics, presumably due to presence of compounds such as saponins, resins and essential oils Beneficial effects for Calendula as an active ingredient: Calendula has anti-inflammatory, antioxidant and antimicrobial activities

50. For increased lubrication and comfort during intercourse Suitable for daily use in cases of vaginal dryness and eases insertion of tampons or a rectal thermometer Safe for use with condoms Adjusted to skin's natural acidity, washes off easily, non-staining, pleasant to the touch, non-greasy and easy to use

52. The perfect solution for intimate hygiene, wherever you are and whatever your activity Handy wipes, easy to carry and convenient to use when travelling outside the home and on trips Helps to prevent unpleasant odors Contains Lactic Acid to enhance the vagina's natural protection, and allantoin to soothe the skin For daily use including during the menstrual period Alcohol free!

53. Natural healing extracts - Allantoin What is Allantoin? Major metabolic intermediate. Beneficial effects for Allantoin a moisturizing and keratolytic effect, increasing the water content of the extracellular matrix and enhancing the desquamation of upper layers of dead skin cells Increasing the smoothness of the skin Promotion of cell proliferation and wound healing Soothing, anti-irritant, and skin protectant effect by forming complexes with irritant and sensitizing agents

54. Contacts: Sigal First – CEO: Gil Shaked – Export Manager:

55. Thank You

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