Department of Pharmacology Overview 2008-2009

1. Department of PharmacologyOverview 2008-2009 Heidi E. Hamm, Ph.D. Earl W. Sutherland, Jr. Professor of Pharmacology Chair, Department of Pharmacology

2. Departmental Interests • Synaptic transmission and neuroscience • Randy Blakely, Ron Emeson, Jeff Conn, Elaine Sanders-Bush, Heidi Hamm, Eugenia Gurevich, Christine Konradi, Qi Zhang, Ana Carneiro, others • Signal transduction • Jeff Conn, Heidi Hamm, Alex Brown, John Exton, Lee Limbird, Seva Gurevich, Brian Wadzinski, Joey Barnett, Bih-Hwa Shieh, Elaine Sanders-Bush, Rich Breyer, others • Biosynthesis and metabolism of metabolites of arachidonic acid • John Oates, Jack Roberts, Alan Brash, Alex Brown, Claus Schneider, Sean Davies, others • Electrical and genetic basis of cardiovascular diseases • Dan Roden, Jeff Balser, Nancy Brown, Al George, Bjorn Knollman, others • Drug Discovery • Jeff Conn, Craig Lindsley, Dave Weaver, Carrie Jones, Scott Daniels, others • Structural Biology • Tina Iverson, Ben Spiller, Seva Gurevich, Heidi Hamm, Jens Meiler

3. Pharmacology Faculty Recruitment PHARMACOLOGY Neuroscience Blakely DeFelice Emeson Gurevich Shieh Stanwood Konradi Carneiro Zhang Clinical Pharmacology Roberts Brash Roden Brown, N Oates Schneider Knollman Davies Drug Discovery Conn Lindsley Jones Daniels Weaver Structural Biology Gurevich Hamm Iverson Spiller Systems Biology Chung Brown Hamm Forster Receptors & Signal Transduction Hamm Sanders-Bush Conn Gurevich Brown, A. Barnett Wadzinski Current search: Signal Transduction

4. HEIDI E. HAMM, PH.D. CHAIR PHARMACOLOGY CONNIE STENQUIST Departmental Administrator GRADUATE STUDIES OFFICE Joey Barnett, Director CHAIR’S OFFICE COMPUTER OFFICE ADMINISTRATIVE OFFICE GRANTS OFFICE Paige Robinson Administrative Officer Sharon Sumrell Business Manager Gordon Borck LAN Manager Karen Gieg Interdisciplinary Program Coordinator E. Elaine Brown Manager Lori Ireton Administrative Assistant I Reception Angela McDonald Administrative Assistant III Chase Jeffords Educational Coordinator II Edward Zhang Computer Tech I Yvonne Smith Administrative Assistant III Purchasing VANDERBILT PROGRAM IN DRUG DISCOVERY P. Jeff Conn, Director Thomas Shaffer LAN Manager Joey Neil Administrative Assistant I Students Kristen Riggs Administrative Officer CENTER FOR MOLECULAR NEUROSCIENCE Randy Blakely, Director Mary Michael, AO Donna Ingram Administrative Manager Tom Ekman Project Consultant Julie Engers Project Consultant DIVISION OF CLINICAL PHARMACOLOGY Nancy Brown, Director Amy Shelton, AO Karin Bargsten Administrative Assistant I Don Hucks Protocol Analyst Lauren Magnifico Administrative Assistant I Departmental Administration Anita Preininger Manager, Research Operations Silvio O. Conte Center for Neuroscience Research Randy Blakely, Director

5. 2008Davies 2009 Carneiro Zhang 2010 Jones Daniels 2010 Signal Transduction Search Recruitment since 2007

6. Christine Konradi is a new Faculty Member in Pharmacology – she joined us from the Psychiatry Department She trained in the Univ. of Vienna, the Univ. of Wurzburg, Univ. of Medicine and Dentistry of New Jersey, and the Mass General Hospital, Harvard Med. School. Our New Faculty Recruits • Christine works on the role of psychostimulants in • gene regulation in psychiatric disorders • She has funding from NIMH, NINDS and NIDA

7. Sean Daviesstudies the lipid products of oxidative stress, the isoketals He is a joint recruit with Clinical Pharmacology He recently received the 2007 NIH Director’s New Innovator Award to develop better long-term treatment strategies for chronic diseases using probiotic bacteria engineered to produce therapeutic compounds. Our New Faculty Recruits

8. Ana Carneiro studies the interactions of integrins with transporters with the goal of understanding the biological function of these interactions; her studies have important implications for depression/cardiovascular disease co-morbidity Our New Faculty Recruits • She was the recipient of a NARSAD Young Investigator • Award and a NIDA research supplement to promote • diversity in health-related research

9. Qi Zhang will join Pharmacology in May to study the regulation of “kiss-and-run” fusion in synaptic regulation He was recruited from Dick Tsien’s laboratory in Molecular & Cellular Physiology at Stanford University Qi has received an NIH “Pathway to Independence” K99/R00 Award Our New Faculty Recruits

10. Scott Daniels is an expert on drug metabolism and pharmacokinetics who did postdoctoral work with Larry Marnett at Vanderbilt and then worked with DuPont Pharma, Millennium and Pfizer in DMPK Our New Faculty Recruits • Scott was recently recruited to be the Head of DMPK for the Vanderbilt Program in Drug Discovery and tenure-track Assistant Professor of Pharmacology

11. Carrie Jones is a systems-level pharmacologist who brings expertise in in vivo behavioral neuropharmacology to the Department. She is Head of the In Vivo/Behavior Group in the Drug Discovery team Our New Faculty Recruits • She trained at Indiana University and Lilly and was part of the preclinical and clinical team who brought fluoxitine (Cymbalta) to market. • She currently has an R01 through NIMH awarded in 2009

12. Promotions • To Associate Professor Chang Chung – promoted to Assoc. Prof. w/o tenure Eugenia Gurevich – in process of promotion to Assoc. Prof. • To Full Professor Ron Emeson Seva Gurevich Joey Barnett Alex Brown Craig Lindsley

13. Reputation Citations NIH funding National Responsibilities & Honors Local leadership roles How are we doing?

14. Chair, Graduate Education Committee, ASPET: Joey Barnett ASBMB Publications Committee: Alex Brown Chair, Neuropharmacology Division, ASPET: Jeff Conn Peer Review Advisory Committee, NIH: Heidi Hamm Chair, Chemistry Coordination Committee, MLPCN: Craig Lindsley Editor-in-Chief, ACS Chemical Neuroscience: Craig Lindsley Editor-in-Chief, Molecular Pharmacology: Jeff Conn Associate Editor, Free Radical Biology & Medicine and Associate Editor, Prostaglandins & Other Lipid Mediators: Jack Roberts HHMI Review Board,Heidi Hamm Our faculty are distinguished leaders nationally and internationally

15. Our faculty are distinguished leaders nationally and internationally • NIMH National Advisory Mental Health Council: Jeff Conn • Scientific Advisory Board, Center of Advanced European Studies and Research: Heidi Hamm • Board of Scientific Counselors, NIMH : Randy Blakely • Board of Scientific Counselors, NIDDK: Jeff Conn • NIMH Council Workgroup on Research Training, Randy Blakely • Chair, American Heart Association Greater Southeast Affiliate Research Committee: Joey Barnett

16. Full Members Joey Barnett Randy Blakely Alex Brown Chang Chung Seva Gurevich Ron Emeson Craig Lindsley Christine Konradi Study Section Members • Ad-hoc Members • Tony Forster • Eugenia Gurevich • Jack Roberts • Gregg Stanwood

17. Randy Blakely: 2008 Axelrod Award, ASPET 2008 ASPET-Astellas Award in Translational Pharmacology Jeff Conn: 2008 PhRMA Foundation Award for Excellence in Pharmacol and Toxicol Craig Lindsley: 2010 ASPET-Astellas Award in Translational Pharmacology Dan Roden: 2008 Rawls Palmer Award for Progress in Medicine, Am Soc for ClinPharmTher Our faculty have received national awards

18. Randy Blakely - Director, Center for Molecular Neuroscience; Director, Conte Center Jeff Conn - Director, Vanderbilt Program in Drug Discovery Craig Lindsley – Director of Medicinal Chemistry and Director of the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development Dan Roden - Director, Oates Institute of Therapeutic Discovery, Asst. Vice-Chancellor for Personalized Medicine Nancy Brown - Chief, Clinical Pharmacology, Associate Dean for Clinical and Translational Scientist Development Our faculty are campus leaders

19. Randy Blakely received the F. Peter Guengerich Awardfor Postdoctoral Mentoring, Vanderbilt University Jeff Conn named the Lee E. Limbird Endowed Professor of Pharmacology, 2008 Nancy Brown- 2008 Elaine Sanders-Bush Faculty Award for Mentoring Our faculty have received Vanderbilt awards

20. Extramural funding $786/sf

21. Our funding has increased dramatically without an increase in departmental budget from the SOM

22. Growth in Department of PharmacologyPublications (Primary Faculty)

23. Nature Neurosci. 1 PNAS 6 Science 1 PLOS Med1 Structure 1 2008-2009 publications in excellent journals • JBC 17 • Biochemistry 10 • ACS ChemBiol 1 • Biophys. J. 7 • Mol Pharm 24 • JPET 4 • J Neuroscience 14 • J Med Chem 10 • J Clin Invest 2

24. Impact of Publications – Pharmacology ISI’s University Science Indicators Vanderbilt ranks # 5 in The Most-Cited Institutions in Pharmacology & Toxicology, 1996-2006

25. This month’s New Hot Paper

26. # of Citations/faculty

27. H Index

28. Randy Blakely 10,147 Alan Brash 9039 Jeff Conn 9871 Heidi Hamm 9498 Jack Roberts 22,002 Top Citations

29. Craig Lindsley: What a trajectory!

30. Elaine Sanders-Bush Symposium endowed Elaine has served as a leader, mentor and role model for her many trainees, her colleagues, and the larger neuroscience community. Elaine has contributed to the success of everyone around her; scores of graduate students and postdoctoral acknowledge Elaine as critical for their success. Her role as the Founding Director of the Vanderbilt Brain Institute made possible an academic home for the first non-departmental PhD training program, in neuroscience, at Vanderbilt, along both integrative and molecular tracks. We celebrated her 48-year career at Vanderbilt at an Inaugural Symposium last month. We are currently raising an Elaine Sanders-Bush Fund in her honor.

31. Web site redesigned

32. Managing fast growth – puts stress on faculty, administration, space Pharmacology is running out of space Departmental Allocation has not changed to meet needs of a larger faculty, more personnel Funding in a flat NIH environment – faculty need to be ever more adventuresome about finding funding; bridge funding is SO appreciated! Economic crisis affects us all, individually, the department, the institution. Our Challenges

33. Strategic Planning Departmental Strategic Planning Session in Dec 2008 • Training student morale: • Students took over organization of the Annual Retreat, Journal Club • Partnership with clinicians: clinical certificate program • Science loss of DMPK, signaling • drove recruitment of faculty in these areas • Administration too much bureaucracy • Fully implemented electronic financial records, ordering, compliance, effort reporting, animal care approval • HR two new tracks: Staff Scientist, Senior Staff Scientist

34. Graduate ProgramStrategic Planning Retreat • Dec. 2009: First ever Strategic Planning Session for • Pharmacology Curriculum; both faculty and students participated • Imagine what kind of training a scientist would need to be • prepared for science in 2020 • One theme: translational approaches from molecule to in vivo • Curriculum redesign • Planning opportunities for moving up some of our • pharmacology coursework to the second semester of the • first year