Medical application of membrane in drug delivery system
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Medical Application of Membrane in Drug Delivery System. NUR HIDAYAH OMAR SITI HAJAR ABU BAKAR ALIA ZULAIKHA MOHD HANIF. INTRODUCTION. Membrane technology is of major importance in medical applications

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Medical Application of Membrane in Drug Delivery System

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Medical application of membrane in drug delivery system

Medical Application of Membrane in Drug Delivery System

NUR HIDAYAH OMAR

SITI HAJAR ABU BAKAR

ALIA ZULAIKHA MOHD HANIF


Introduction

INTRODUCTION

  • Membrane technology is of major importance in medical applications

  • Used in drug delivery, artificial organs, tissue regeneration, diagnostic devices, as coatings for medical devices, bioseparations, etc.

  • Delivery system is to deliver a drug to a specific site, in specific time and release pattern.


Membrane based system

Membrane –based system

  • Membrane-based systems basically a drug reservoir is contained in a membrane device.

    Two types of systems can be distinguished:

    • Osmotic membrane systems.

    • Diffusion controlled membrane systems.


Osmotic membrane system

Osmotic Membrane System

  • Consists of a reservoir made of a polymeric membrane permeable to water but not to the drug (semi-permeable membrane).

  • The reservoir contains a concentrated drug solution. As water crosses the membrane due to osmotic pressure, the drug solution is released through the orifice.


Diffusion controlled membrane syste m

Diffusion Controlled Membrane System

  • The drug release is controlled by transport of the drug across a membrane.

  • The transport is dependent on the drug diffusivity through the membrane and the thickness of the membrane

  • The membrane can be porous or non-porous and biodegradable or not.


Liposome

LIPOSOME

  • An artificially-prepared vesicles composed of a lipid bilayer.

  • Used as a vehicle for administration of nutrients and pharmaceutical drugs.

  • Composed of natural phospholipids, and contain mixed lipid chains with surfactant properties

  • Liposomes vary in size due to their medication type like DNA, enzyme, drugs, and supplementation .


Targeted delivery

Targeted delivery

  • Liposomes prepared from natural or synthetic phospholipids containing an encapsulated drug. This type of drug delivery reduces toxicity, maintains or enhances activity and facilitates accumulation in the disease site.

  • Conventional liposornes that incorporate lipids enhancing circulation lifetimes. Delivery in these molecules improves access to the disease site and reduces interaction with phagocytic cells of the reticulo-endothelial system.


Medical application of membrane in drug delivery system

  • Conventional liposomes with lipids that enhance circulation lifetimes and have

  • surface-associated targeting information. Drug delivery using this type of liposome results in an improved therapeutic index and target cell

  • specific delivery.

  • Examples; antibodies (glycolipids and mannose), proteins (e.g. Transferrin and asialofetuin) , and vitamins (e.g. folic acid have been used to target specific cells via cell surface receptors

  • Fusogenicliposomes with DOPE or fusogenic proteins. This method allows intracellular drug delivery.

  • DOPE has been particularly useful for cationic liposomescomplexed with plasmid DNA for gene delivery.


Applications of m embrane system

Applications of Membrane System

Pills

  • The diffusion principle is applied to pills and tablets.

  • The drug is pressed into tablet which is coated with a non-digestible hydrophilic membrane.

  • Once this membrane gets hydrated, a viscous gel barrier is formed, through which the drug slowly diffuses.

  • The release rate of the drug is determined by the type of membrane used


Medical application of membrane in drug delivery system

Implants

  • consist of a membrane reservoir containing a drugin liquid or powder form

  • The drug slowly diffuses through the semi-permeable membrane and the rate of diffusion depends on the characteristics of both the drug and membrane.

  • The thickness of the membrane is constant to secure uniformity of drug delivery.


Medical application of membrane in drug delivery system

  • If the membrane degrades, drug delivery should be accomplished prior to membrane degradation.

  • If the membrane is made of non-degradable material, it should be surgically removed afterwards.

  • A drawback of implants is the risk of membrane rupture resulting in drug-dumping: a sudden release of large amounts of drugs


Medical application of membrane in drug delivery system

Patches

  • Patches are broadly used in drug delivery.

  • The most characteristic examples are ocular (eye) and transdermal patches.

  • Ocular patches are typical membrane-controlled reservoir systems. The drug, accompanied by carriers, is captured in a thin layer between two transparent, polymer membranes, which control the rate of the drug release


Medical application of membrane in drug delivery system

  • An annular white-coloured border is surrounding the reservoir for handling of the device.

  • The device is placed on the eye, where it floats on the tear film.

  • Through diffusion, the drug is directly administered to the target area.


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