Pattern of Polymorphism After Strong Artificial Selection in a Domestication Event Hidenki Innan and Yuseob Kim. A Summary By William Dotson and Danny Rose. Outline of the Presentation. Background Information Experimental Methods and Results Discussion and Implications.
William Dotson and Danny Rose
Find domestication genes primarily in crops such as corn and rice
Equilibrium – the genotype of a chromosome at one locus is independent of its genotype at the other locus
Selection and Linkage Disequilibrium
- qS variation in segregating site
-qpvariation of pairwise nucleotide differences
-qHhomozygosity of the derived allele per site
Simulation of a Domestication Event – Bottleneck
Current Population N1
Ancestral Population N2
Neutral Allele in Wild Progenitor Population (Genetic Drift)
Subset Founder Population and Artificial Selection Begins (td)
Polymorphism with Selection
Standard Selective Sweep Model
Measured the effects of
Statistical Tests for Selection
These statistical tests were used to analyze the simulations to detect a signature of selection.
These tests supported the theoretical model in that it followed the patterns of polymorphism and selection.