orthomyxoviridae human influenza viruses
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Orthomyxoviridae: human influenza viruses. Poxviridae. Retroviridae: HIV. Enveloped viruses versus membrane-containing viruses. Alphaviruses Flaviviruses. HSV / f 6. PRD1. PM2 ?. Bacteriophage PRD1. “penton”. outer leaflet. DNA. inner leaflet. PRD1 structural proteins.

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Presentation Transcript
enveloped viruses versus membrane containing viruses
Enveloped viruses versusmembrane-containing viruses

Alphaviruses

Flaviviruses

HSV / f6

PRD1

PM2 ?

slide6

“penton”

outer leaflet

DNA

inner leaflet

prd1 structural proteins
PRD1 structural proteins

P3 major coat 43 kDa x

P30 minor coat 9 kDa x

P2 receptor binding 64 kDa

P5 spike 34 kDa

P31 penton 14 kDa x

CAPSID

VERTICES

P6 portal 18 kDa

P9 packaging ATPase 26 kDa

P20 DNA packaging (M) 5 kDa

P22 DNA packaging (M) 6 kDa

PACKAGING

VERTEX

P7 transglycosylase (M) 27 kDa

P14 DNA delivery (M) 15 kDa

P15 muramidase 17 kDa

P16 infectivity (M) 13 kDa x

P18 DNA delivery (M) 10 kDa

P32 DNA delivery (M) 5 kDa

P34 (M) 7 kDa

ENTRY

(M) integral membrane protein

slide9

David Stuart

Nicoal Abrescia

slide11

John Briggs

Retroviruses

Asymmetric

Variable in diameter

Envelopment requires both viral and cellular proteins

Membrane plays role in both assembly and maturation

slide12

George J Thomas

Escherichia coli

slide14

irido

adeno

PRD1

Lineage 1

Lineage 2

Lineage 3

phi6

BTV

herpes

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