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Canine Renal Tumors

Canine Renal Tumors. Trisha J. Oura Radiology Resident August 24, 2009. Callie Baxter #124115. 11 yo FS Golden Retriever Multiple problems!. the inspiration…. Primary Renal Neoplasia. Rarely diagnosed in dogs 1 % of canine neoplasia Origin Epithelial Mesenchymal Embryonal

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Canine Renal Tumors

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  1. Canine Renal Tumors Trisha J. Oura Radiology Resident August 24, 2009

  2. Callie Baxter #124115 • 11 yo FS Golden Retriever • Multiple problems! the inspiration…

  3. Primary Renal Neoplasia • Rarely diagnosed in dogs • 1 % of canine neoplasia • Origin • Epithelial • Mesenchymal • Embryonal • Malignant vs. Benign • Adenomas = 15% of canine renal neoplasia • Hemangioma • Survival • Varies: 0-16 mo ** cystadenocarcinomas in GSD with nodular dermatofibrosis

  4. Byran J., et al. Primary renal neoplasia of dogs. J Vet Intern Med 2006;20:1155-1160. • Retrospective 82 cases primary renal neoplasia • Biopsy/FNA (US-guided), surgical biopsy, necropsy • Excluding lymphoma (primary vs. multicentric?) • Older (~8yo) • ♂ = ♀? • Cocker spaniel, Labrador

  5. 49/82 = Carcinoma Renal TCC Tubular [papillary] adenocarcinoma Renal adenocarcinoma Renal tubular carcinoma Clear cell carcinoma Papillary cystadenocarcinoma 28/82 = Sarcoma HSA Renal sarcoma [Fibro] Leiomyosarcoma Histiocytoma Spindle cell sarcoma 5/82 = Nephroblastoma Results of retrospective

  6. Clinical signs/PE Hematuria Palpable mass PUPD ADR, wt loss, vomiting, pain (sarcoma??) Clinpath Nonspecific Azotemia, leukocytosis Hematuria, pyuria proteinuria, isosthenuria Imaging Thoracic radiographs 16 % metastatic (vs. 48%?) 61% at necropsy Abdominal radiographs 89% mass identified Abdominal ultrasound 93% mass identified Diagnosis

  7. Ultrasound appearance “…homogenous or heterogenous, hypoechoic, isoechoic, hyperechoic, regular or irregular lesions with variably well-defined margins..”

  8. Ultrasound appearance • Solid (cortical/medullary) • Just about ANYTHING! • Hypoechoic nodules/masses: LSA? Malig histiocytosis? • Possible areas of hemorrhage, necrosis, calcification (complex masses) • Vascularity varies • DDX: [pyo]granuloma, abscess, cyst, hematoma, • Pelvic lesions: non shadowing lesion (ddx: clot, debris, inflammatory mass)

  9. While you’re scanning… • Metastases (adrenal, cava, liver, contralateral kidney) • Retroperitoneal effusion • FNA, Biopsy • CT When in doubt before cutting it out…

  10. References • Byran J, et al. Primary renal neoplasia of dogs. J Vet Intern Med. 2006;20:1155-1160. • D’Anjou, M. Kidneys and ureters. In: D’Anjou M, Penninck D, eds. Atlas of small animal ultrasonography. Ames: Blackwell Publishing, 2008; 339-364. • Maxie MG, Newman SJ. Renal neoplasia. In: Maxie MG, ed. Jubb, kennedy, and palmer’s pathology of domestic animals. 2nd vol. 5th ed. Philadelphia: Elsevier Saunders, 2007; 499-502. • Nyland TG, et al. Urinary tract. In: Nyland TG, Mattoon JS, eds. Small animal diagnostic ultrasound. 2nd ed. Philadelphia: WB Saunders Co, 2002; 158-195.

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