Nonsteroidal Antiinflammatory Drugs (NSAIDs) . Inflammation is a defense reaction caused by tissue damage or injury Can be elicited by numerous stimuli including : infectious agents antigen-antibody interaction ischemia thermal and physical injury. Characterized by:
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Mediators of Inflammation or injury
Two main forms of or injuryCyclooxygenases (COX)
Drug interactions esterases to acetic acid and the active metabolite