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Prepare for Personalized Medicine. Family Health History – An important first step in risk assessment for genetic diseases and other hereditary health conditions. Genetic Family History.

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Prepare for Personalized Medicine

FamilyHealth History –

An important first step in risk assessment for genetic diseases and other hereditary health conditions


Genetic Family History

“Health care professionals have known for a long time that common diseases (such as heart disease, cancer, and diabetes), and even rare diseases (like hemophilia, cystic fibrosis, and sickle cell anemia) can run in families. If one generation of a family has high blood pressure, it is not unusual for the next generation to have similarly high blood pressure. Tracing the illnesses suffered by parents, grandparents, and other blood relatives can help predict the disorders to which your patient may be at risk and take action to keep your patient and family healthy.”

– http://www.hhs.gov/familyhistory/


Genetic Family History – My Family Health Portrait

  • “The family tree has become the most important genetic test of all…”

  • To help focus attention on the importance of family health history, U.S. Surgeon General in cooperation with other agencies within the U.S. Department of Health and Human Services (HHS) has launched a national public health campaign, called the U.S. Surgeon General's Family History Initiative, to encourage all American families to learn more about their family health history. http://www.hhs.gov/familyhistory/


My Family Health Portrait

  • Americans know that family history is important to health. A recent survey found that 96 percent of Americans believe that knowing their family history is important. Yet, the same survey found that only one-third of Americans have ever tried to gather and write down their family's health history. http://www.hhs.gov/familyhistory/


My Family Health Portrait

  • Because family health history is such a powerful screening tool, the Surgeon General has created a new computerized tool to help make it fun and easy for anyone to create a sophisticated portrait of their family's health. http://www.hhs.gov/familyhistory/


National Family History Day

  • Thanksgiving is an annual National Family History Day. Thanksgiving is the traditional start of the holiday season for most Americans.

  • Whenever families gather, the Surgeon General encourages them to talk about, and to write down, the health problems that seem to run in their family. Learning about their family's health history may help ensure a longer future together.

  • http://www.hhs.gov/familyhistory/


Family history is a risk factor for diseases throughout all stages of life

diabetes

depression

Alzheimer’s disease

osteoporosis

birth defects

blood disorders

infants

adolescents

older adults

children

adults

asthma

autism

cancer

heart disease


Betty s story in 2017
Betty’s Story in 2017 stages of life

  • Betty completes the Surgeon General’s family history tool at age 18, learns of uncles with early heart disease

  • She consults her M.D., who suggests complete genome sequencing for $1000

  • She inquires about the risk of genetic discrimination, but federal legislation has outlawed this


Betty s story continues
Betty’s Story Continues… stages of life

  • She is found to have three gene variants that well validated studies have conclusively shown increase risk of early heart attack 5-fold

  • She and her M.D. design a program of prevention based on diet, exercise, and medication precisely targeted to her genetic situation


Betty s story continues1
Betty’s Story Continues… stages of life

  • Betty does well until age 75

  • She develops left arm pain that she assumes is due to gardening, but her M.D. knows her higher risk and diagnoses an acute MI

  • Referring to her genome sequence, the drugs that will work best to treat her are chosen

  • She survives and is alive and well in the 22nd century



Betty s story gone wrong
Betty’s Story Gone Wrong Nightmare?

  • The Surgeon General’s Family History Initiative never really takes off and her M.D. is too busy to ask about family history, so Betty never learns about her family history.

  • Betty is offered genome sequencing, but after seeing her brother lose his health insurance from this information, she declines.


Betty s story gone wrong1
Betty’s Story Gone Wrong Nightmare?

  • Betty eats an unhealthy diet, gains weight, and develops hypertension.

  • While tests to predict which drug would be most effective for Betty have been proposed, they have never been validated, and are not reimbursed.

  • Betty’s hypertension is treated with a drug that causes a hypersensitivity reaction, so she stops treatment.


Betty s story gone wrong2
Betty’s Story Gone Wrong Nightmare?

  • After 10 years of uncontrolled hypertension, Betty develops left arm pain at age 45.

  • Her M.D., unaware of her high risk, assumes this is musculoskeletal and prescribes rest.

  • Betty returns to the ER the next day in cardiogenic shock.


Betty s story gone wrong3
Betty’s Story Gone Wrong Nightmare?

  • The absence of her genome sequence information prevents optimal choice of therapy.

  • Betty dies in the ER.


Executive summary
Executive Summary Nightmare?

  • Will all this genomic Health Care stuff really help lead to patient-centered and truly personalized Health Care?


Executive summary1
Executive Summary Nightmare?

“Our age may be known to history as the age of genetic medicine, a time when many of the most feared illnesses were overcome.”

- President Bush April 10, 2002


Executive summary2
Executive Summary Nightmare?

“It is now conceivable that our children's children will know the term cancer only as a constellation of stars.”

- President Clinton

June 26, 2000


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