Computer aided medicine modeling and simulation for physiological s ystems
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Computer Aided Medicine Modeling and Simulation for Physiological S ystems. LIU Lei Shanghai Center for Bioinformation Technology 03/05/2013. Methods. Introduction. Examples. 1. 2. 3. Outlines. Introduction.

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Computer Aided Medicine Modeling and Simulation for Physiological S ystems

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Computer Aided MedicineModeling and Simulation for Physiological Systems

LIU Lei

Shanghai Center for Bioinformation Technology

03/05/2013


Methods

Introduction

Examples

1

2

3

Outlines


Introduction

  • Modeling and simulation is a discipline for developing a level of understanding of the interaction of the parts of a system, and of the system as a whole.

  • It is widely used in many fields

    • Industry

    • Social affairs

    • Transportation

    • Life sciences


;

;

Why simulation


Introduction

System

Computer

Modeling

Simulation

Model


Introduction

System

----Democritus Great World System


Introduction

System


Introduction

Model


Introduction

Model


Introduction


Introduction

Model


Introduction

Model


Introduction

  • 1961G.W.Morgenthater

  • 1978Korn

Simulation


Introduction

  • 1982Spriet

  • 1984Oren

Simulation

--


Introduction

Simulation

simulation

Models


Introduction

  • Nowadays, the modern simulation technology is done by computers, so system simulation is sometimes called computer simulation

Simulation


Three important factors of system simulation

System model computer

Introduction

System

Model

Simulation

Model

Emulator or Computer

Modeling


History of System Modeling and Simulation


Different kinds of simulation


Similarity

Geometric similarity

Environment similarity

Function similarity

Similarity of thinking

Physical similarity

Foundation of simulation


New trends of simulation

    • object-oriented simulation

    • qualitative simulation

    • intelligence simulation

    • distributed interactive simulation

    • visual simulation

    • multimedia simulation

    • virtual reality simulation


mathematical model

modeling method

model verification

System modeling


(time-invariant systems)

Mathematical model


Modeling method





Physiological systems are any systems that contribute to the functioning of the human body. These may include any of the organs, for example:

cardiovascular system (blood vessels and heart)

nervous system (brain, spinal cord and nerves)

respiratory system (lungs, associated blood supply and bronchial tree)

renal system (kidney filtration)

endocrine system (hormone production, release and action)

Physiological systems


Animal experiment

Human experiment

Modeling and simulation of physiological systems

Physical Simulation

Computer aided simulation

Methods to study Physiological systems


Modeling methods





()


,







SCIRun

  • SCIRun is a Problem Solving Environment (PSE), for modeling, simulation and visualization of scientific problems.

    • SCIRun now includes the biomedical components formally released as BioPSE, as well as BioMesh3D.

    • SCIRun is available for free and is open source.

    • http://www.sci.utah.edu/cibc/software/106-scirun.html


SCI Run

  • SCIRun is developed and maintained by the NIH/NCRR Center for Integrative Biomedical Computing

  • It runs on Unix, Mac, Linux

  • The latest version is SCIRun 4.7, and the stable version is 4.6

  • One can get it from http://www.sci.utah.edu/download/scirun/4.6.html


SCIRun

  • SCIRun is a modular dataflow programming Problem Solving Environment (PSE).

  • SCIRun has a set of Modules that perform specific functions on a data stream. Each module reads data from its input ports, calculates the data, and sends new data from output ports.


SCIRun


SCI Run


References


Thank you !

11/05/2011


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