HOW CAN NEUROIMAGING HELP UNDERSTAND, DIAGNOSE, AND DEVELOP TREATMENTS FOR ALZHEIMER'S DISEASE? Part A – AD definition, neuropath?. NUCLEAR MEDICINE GRAND ROUNDS Stanford University J. Wesson Ashford, M.D., Ph.D. Clinical Professor (affiliated), Department of Psychiatry and Behavioral Sciences
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NUCLEAR MEDICINE GRAND ROUNDS
J. Wesson Ashford, M.D., Ph.D.
Clinical Professor (affiliated), Department of Psychiatry and Behavioral Sciences
Senior Research Scientist, Stanford / VA Aging Clinical Research
Stanford University and VA Palo Alto Health Care System
January 5, 2010
Slides at: www.medafile.com(Dr. Ashford’s lectures)
1. Multiple Cognitive Deficits
2. Other Cognitive Impairment
1. Other CNS Conditions
2. Substance Induced Conditions
Reprinted with permission from Brumback, RA, Leech RW, J. Ohio State Med Assoc. 1994: 87, 103-111
Yesavavage et al., 2002 Ohio State Med Assoc. 1994: 87, 103-111
Normal Brain Ohio State Med Assoc. 1994: 87, 103-111
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Specific groups of cholinergic, serotonergic, and noradrenergic that project to the cortex, and glutamatergic neurons of discrete cortical regions are selectively affected in Alzheimer’s disease
Discrete regions of the cerebral cortex are selectively affected by Alzheimer pathology
Brun & Englund, 1986
Braak & Braak, 1991; Braak et al., 2006 affected by Alzheimer pathology
(Braak & Braak, 1991) affected by Alzheimer pathology
Braak & Braak, 1991 affected by Alzheimer pathology
S. Arnold, Cortex, 1991