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Chapter 28

Chapter 28. The Reproductive System. The Reproductive Systems. Reproductive organs grouped by function Gonads - testes and ovaries produce gametes and secrete hormones production of gametes, fluid, discharge into ducts indicate exocrine glands

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Chapter 28

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  1. Chapter 28 The Reproductive System

  2. The Reproductive Systems • Reproductive organs grouped by function • Gonads - testes and ovaries • produce gametes and secrete hormones • production of gametes, fluid, discharge into ducts indicate exocrine glands • production of hormones indicate endocrine glands • Ducts - transport, store, receive gametes • Accessory sex glands - gamete support • Supporting structures - various reproductive roles

  3. Male Reproductive System • Testes, system of ducts, accessory sex glands, several supporting structures (including penis)

  4. Male Reproductive System • Scrotum • 2 sacs that support testes • muscle and connective tissue • dartos muscle and fascia • cremaster muscle • location and temperature due to muscle contraction • sperm production requires temp 3 C below body temp • muscle contraction raises and lowers testes

  5. Male Reproductive System • Testes - testicles • paired oval glands 5 cm x 2.5 cm • develop in abdomen • begin to descend during 7th month of development • cryptorchidism

  6. Male Reproductive System • Testes surrounded by connective tissue • covered by tunica vaginalis (serous membrane) from peritoneum • more internal is tunica albuginea • forms septa and lobules • 200-300/testicle

  7. Male Reproductive System • 3 seminiferous tubules - each lobule • Each tubule lined w/ spermatogenic cells in various developmental stages

  8. Male Reproductive System • Spermatogonia to spermatazoa • Sustentacular (Sertoli) cells • blood-testis border • mediate testosterone FSH effects • phagocytize excess spermatid cytoplasm • control movement and sperm release to tubule • secrete fluid for sperm transport • Interstitial endocrinocytes (interstitial cells of Leydig) • located between tubules • secrete testosterone

  9. Male Reproductive System • Spermatogenesis • occurs in seminiferous tubule • production of haploid spermatozoa • about 74 days in humans • Spermatogonia • diploid • w/ mitosis some stay as stem cells • some undergo developmental changes  primary spermatocytes

  10. Male Reproductive System • Reduction division • secondary spermatocytes formed (haploid) • equatorial division • spermatids formed (haploid) • sperm cells do not completely separate • maintain cytoplasmic bridges due to incomplete nature of Y chromosome • Spermiogenesis • maturation of spermatids into spermatozoa • 10-14 days for maturation in ductus epididymus

  11. Male Reproductive System • Spermatozoa • 300 million/day mature • survive about 48 hrs following ejaculation • structure • head • nuclear material • acrosome - enzymes for penetration into egg • midpiece - site of metabolism for tail • tail - flagella

  12. Male Reproductive System • Hormones of brain-testicular axis • anterior pituitary drives changes during puberty • begins to secrete FSH, LH • controlled by GnRH from hypothalamus • LH - Interstitial endocrinocytes • testosterone • DHT • FSH - Sustentacular cells • ABP • Inhibin

  13. Male Reproductive System • Development • testosterone stimulates pattern development before birth (internal ducts) • DHT external genitals • estrogens from testes - brain development • Puberty - testosterone, DHT stimulate enlargement of male sex organs and secondary sexual characteristics

  14. Male Reproductive System • Testosterone - the gift that keeps on giving! • 2 sex characteristics • muscular, skeletal growth • heavier, thicker muscle, bones in men than women • also epiphyseal closure • pubic, axillary, facial and chest hair • oil gland secretion • larynx enlargement • sexual functions • male sexual behavior and aggression • spermatogenesis • sex drive in both male and female • metabolism - stimulates protein synthesis

  15. Male Reproductive System • Ducts • sperm and semen to lumen of seminiferous tubules  straight tubules  rete testis  epididymis • new sperm, fluid produce pressure to move things along • fluid - androgens, estrogens, K+, glutamic acid, aspartic acid

  16. Male Reproductive System • Epididymis • posterior border of testes • tightly coiled tube - head, body, tail • 6 m long if uncoiled • pseudostratified columnar epithelium • microvilli • reabsorb degenerated sperm • ductus epididymis • site of sperm maturation (10-14 days) -  motility • may remain in storage for a month, then reabsorbed

  17. Male Reproductive System • Ductus (vas) deferens • less convoluted,  diameter • ascends, enters pelvic cavity through inguinal canal • loops up, over urinary bladder ends in ampulla

  18. Male Reproductive System Posterior View

  19. Male Reproductive System • Spermatic cord - testicular artery, autonomic nerves, veins, lymphatic vessels, cremaster muscle ascend w/ vas deferens • Enter body through inguinal canal • Vasectomy - portion of each duct removed

  20. Male Reproductive System • Ductus (vas) deferens • pseudostratified columnar epithelium w/ heavy coat of muscle • stores, conveys sperm from epididymis to urethra during ejaculation • peristalsis

  21. Male Reproductive System • Ejaculatory Ducts • formed by ducts from seminal vesicle and ductus deferens • move sperm into prostatic urethra before ejaculation

  22. Male Reproductive System • Urethra • terminal tract of urinary, reproductive systems • 3 areas: • prostatic urethra • membranous urethra • spongy (cavernous) urethra • ends at external urethral orifice in bulb of penis

  23. Male Reproductive System • Accessory sex glands secrete liquid portion of semen • Seminal vesicles • base of urinary bladder •  60% of semen volume • secrete alkaline viscous fluid containing: • fructose, ascorbic acid • prostaglandins • vesiculase (coagulating enzyme)

  24. Male Reproductive System • Prostate • below bladder, around urethra • secretes milky, slightly acidic fluid with: • citrate • enzymes • Phosphatase • Fibrinolysin • Prostate specific antigen (PSA) • Bulbourethral (Cowper's) glands • beneath prostate gland at membranous urethra • secrete: • alkaline substance • Mucous • neutralize any acidic urine

  25. Male Reproductive System

  26. Male Reproductive System • Semen - mixture of sperm and secretions • avg vol 2.5-5 ml • 50-150 million sperm/ml • below 20 million/ml infertility • large numbers needed • slightly alkaline (7.2-7.6), milky and mucoid • decreases acidity of vagina • fructose for fuel • prostaglandins decrease mucous viscosity and reverse peristalsis • contains antibiotic • coagulates after ejaculation into vagina • different mechanism than blood clotting • breaks down in 5-20 minutes

  27. Male Reproductive System • Penis • root (attachment) • body (shaft) • glans penis

  28. Male Reproductive System • Root of penis - bulb (base of corpus spongiosum) • Glans penis w/ outer corona • terminal slitlike opening (external urethral orifice) • covering is prepuce (foreskin)

  29. Male Reproductive System • Body • 3 cylindrical masses of tissue surrounded by tunica albuginea • dorsolateral corpora cavernosa penis • midventral corpus spongiosum penis w/ spongy urethra • all surrounded by fascia and skin • each have blood sinuses

  30. Male Reproductive System • Erection • arteries dilate w/ sexual stimulation - PNS reflex • large quantities of blood enter sinuses • compress superficial veins from sinuses • trapped blood  erection • close bladder sphincter • prevent urine flow • prevent semen backflow • Ejaculation • sympathetic reflex • peristalsis • arterial vessels constrict, sinuses empty

  31. Female Reproductive System • Ovaries, uterine (Fallopian) tubes, uterus, vagina, vulva, mammary glands

  32. Female Reproductive System • Ovaries • paired organs in pelvic cavity • supported by several ligaments • almond size • homologous to testes

  33. Female Reproductive System • Ovary Histology • germinal epithelium around outside • tunica albuginea - connective tissue • stroma - connective tissue • cortex - outer dense layer w/ ovarian follicles • medulla - inner loose layer • ovarian follicles • vesicular ovarian (Graafian) follicle • corpus luteum

  34. Female Reproductive System • Oogenesis - formation of haploid ova in ovary • Steps • Reduction division - meiosis I • starts during fetal development, pauses • finishes after puberty • Equatorial division - meiosis II • pauses • finishes after fertilization

  35. Female Reproductive System • Uterine (Fallopian) tubes - oviducts • extend laterally from uterus to carry ova from ovaries to uterus • structure • infundibulum with fimbriae • ampulla • isthmus

  36. Female Reproductive System • Once a month ovarian follicle ruptures releasing secondary oocyte (ovulation) • oocyte swept into oviduct by fimbriae moves by peristalsis, cilia • fertilization can occur any time in next 24 hours • generally in ampulla • becomes a zygote • unfertilized oocytes disintegrate

  37. Female Reproductive System

  38. Female Reproductive System • Uterus • site of menstruation, implantation, fetal development, labor • between urinary bladder and rectum • size, shape of inverted pear

  39. Female Reproductive System • 3 parts of Uterus • fundus • body - isthmus

  40. Female Reproductive System • cervix • narrow portion that opens into vagina • produces cervical mucous; (20-60 ml/day) • more receptive to spermatazoa at or near ovulation • otherwise  mucous plug • cervix, mucus • protect spermatazoa • provide nutrients • role in capacitation • Cervical canal in cervix • internal os • external os

  41. Female Reproductive System • Uterus bends between body and cervix • Uterus enters vagina at right angle

  42. Female Reproductive System • Ligaments provide stability • broad ligaments • uterosacral ligaments • cardinal ligaments • round ligaments

  43. Female Reproductive System • 3 uterine layers • Perimetrium - visceral peritoneum • Myometrium • 3 layers of smooth muscle • thickest in fundus • thinnest in cervix • expulsion

  44. Female Reproductive System • Endometrium • highly vascular • surface layer • simple columnar epithelium • ciliated, secretory cells • uterine (endometrial) glands

  45. Female Reproductive System • Endometrium - divided into 2 layers: • stratum functionalis (functional layer) - shed during menstruation • stratum basalis (basal layer) - gives rise to stratum functionalis

  46. Female Reproductive System • Blood supply from uterine arteries • arcuate arteries - circular around myometrium • radial arteries penetrate into myometrium w/ 2 branches: • straight arterioles • terminate in basilis • supply materials to regenerate functionalis • spiral arterioles • penetrate functionalis • change during menstruation • Drained by uterine veins

  47. Female Reproductive System • Endoparasitic expulsion

  48. Female Reproductive System • Vagina • Tubular, fibromuscular organ with mucous membrane • Between bladder, rectum • superiorly attached to uterus • recess (fornix) around attachment to cervix • Several functions • passage for menstrual flow, childbirth • receives semen

  49. Female Reproductive System • Vagina histology • Mucosa continuous w/ uterus • non-keratinized stratified squamous epithelium and connective tissue in folds (rugae) • mucosal cells have large stores of glycogen • upon decomposition produce organic acids - lo pH • dendritic (APC) cells - AIDS? • Muscularis • smooth muscle - outer circular, inner longitudinal • stretches to receive penis and for childbirth • Adventitia - areolar connective tissue

  50. Female Reproductive System • Mons pubis • Anterior to vaginal, urethral openings • Adipose tissue covered by skin, hair • Labia majora • Lateral skin folds (adipose tissue) with sebaceous and sudoriferous glands • Homologous to scrotum • Labia minora • Smaller, medial folds with sebaceous glands • Homologous to spongy urethra • Vulva - pudendum • Female external genitalia this is a test

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