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SEX LINKED INHERITANCE. Sex Determination: The human XY system Nondisjunction: The failure of chromosomes to separate properly during one of the stages of meiosis (fig. 11-12) This can produce gametes w/two sex chromosomes or no sex chromosomes. Results in abnormal # of sex chromo.

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SEX LINKED INHERITANCE

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Sex linked inheritance l.jpg

SEX LINKED INHERITANCE

Sex Determination: The human XY system

Nondisjunction: The failure of chromosomes to separate properly during one of the stages of meiosis (fig. 11-12)

This can produce gametes w/two sex chromosomes or no sex chromosomes. Results in abnormal # of sex chromo.

Nondisjunction disorders

Turner syndrome- female in appearance, w/o sex organs

45X or 45XO

Klinefelter syndrome- Male in appearance, sterile, 47XXY

Babies are not born without an X chromosome

What can we learn? X chromo. Is essential; gender is determined by presence/absence of Y


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NONDISJUNCTION DISORDERS


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SEX-LINKED INHERITANCE


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SEX-LINKED GENETIC DISORDER

  • Sex-linked: Genes carried on the X or Y Chromo. Which are expressed more commonly in males. WHY?

  • COLORBLINDNESS- Most caused by genes located on X chromo.

  • Red-green is most common, 8% males; 1% females

  • Carried on X chromo.; dominant allele is XC & recessive is Xc.

  • Why more common in males?

  • HEMOPHILIA- Bleeders disea

  • se, protein AHF is missing.

  • MUSCULAR DYSTROPHY- Progressive wasting away of muscle.

  • Caused by defective version of the gene, dystrophin

  • SEX-INFLUENCED TRAITS: Caused by a gene whose expression differs in males & females, located on autosomes.


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SEX-LINKED DISORDERS


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