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Gene Panel Training session. Valairat Dhamcharee , M.D. Diplomate American Board of Medical Genetics Diplomate American Board of Neonatal Perinatal Medicine Diplomate American Board of Pediatrics. Take a more active role in managing your health. Goal.

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gene panel training session

Gene PanelTraining session

ValairatDhamcharee, M.D.

Diplomate American Board of Medical Genetics

Diplomate American Board of Neonatal Perinatal Medicine

Diplomate American Board of Pediatrics

slide3
Goal
  • 1. Be on the lookout for common conditions
  • 2. Prepare for serious diseases
  • 3. Prevention of the unforeseen threats
  • 4. Make better lifestyle choices

Valairat Dhamcharee, M.D.

slide4

Target group: All age

Test: Genetic markers

Method: Saliva collection by Saliva kit

benefits
Benefits
  • Early detection
  • Prevention
  • Treatment
  • Possible reversal of age-related disorders

Valairat Dhamcharee, M.D.

categories of testings
Categories of Testings
  • 1. Cardiovascular
  • 2. Metabolic
  • 3. Eye and vision
  • 4. Degenerative disorders
  • 5. Bones and joints
  • 6. Cancers
  • 7. Carrier status
  • 8. Drug response and side effects

Valairat Dhamcharee, M.D.

cardiovascular
Cardiovascular
  • Abdominal Aortic Aneurysm
  • Atrial Fibrillation
  • Heart Attack
  • Hypertension
  • Peripheral Arterial Disease
  • Venous Thromboembolism

Valairat Dhamcharee, M.D.

metabolic
Metabolic
  • Obesity
  • Type 1 Diabetes
  • Type 2 Diabetes

Valairat Dhamcharee, M.D.

eye and vision
Eye and vision
  • Age Related Macular Degeneration

Valairat Dhamcharee, M.D.

degenerative disorders
Degenerative disorders
  • Alzheimer’s Disease
  • Essential Tremor
  • Multiple Sclerosis

Valairat Dhamcharee, M.D.

bones and joints
Bones and joints
  • Gout
  • Rheumatoid Arthritis
  • Osteoarthritis

Valairat Dhamcharee, M.D.

cancers
Cancers
  • Basal Cell Carcinoma
  • Bladder Cancer
  • Breast Cancer
  • Colorectal Cancer
  • Lung Cancer
  • Ovarian Cancer
  • Pancreatic Cancer
  • Prostate Cancer
  • Testicular Cancer
  • Thyroid Cancer

Valairat Dhamcharee, M.D.

male testings
Male testings
  • Cardiovascular
  • Metabolic
  • Eye and vision
  • Degenerative disorders
  • Bones and joints
  • Cancer: Prostate, testicular

Valairat Dhamcharee, M.D.

female testings
Female testings
  • Cardiovascular
  • Metabolic
  • Eye and vision
  • Degenerative disorders
  • Bones and joints
  • Cancer: Breast, ovarian
  • SLE

Valairat Dhamcharee, M.D.

carrier testing
Carrier Testing
  • Thalassemia
  • Metabolic disorders

Valairat Dhamcharee, M.D.

drug response
Drug Response
  • Alcohol Consumption
  • Smoking and health risk
  • Antidepressant Response
  • Beta-Blocker Response
  • Caffeine Metabolism

Valairat Dhamcharee, M.D.

what we are testing to determine a genetic risk
What we are testing to determine a genetic risk?
  • We are looking at “SNP” (Single Nucleotide Polymorphism) or “Genetic marker”.

Valairat Dhamcharee, M.D.

genetics is who we are
Genetics is who we are
  • Most of your physical traits, such as eye color, hair color, and height, are inherited. So, too, are risks for health problems, such as heart disease, diabetes, and some cancers.
  • In fact, all diseases or medical conditions have a genetic component (except trauma).

Valairat Dhamcharee, M.D.

slide19

What are we made of?

Valairat Dhamcharee, M.D.

how important is dna
How important is DNA?
  • Your DNA affects every aspect of your health by helping to shape your risks for many different health conditions.
  • DNA is 99.9% identical among humans.
  • All our variations of shape, size and color are within that remaining 0.1% (DNA variants).

Valairat Dhamcharee, M.D.

human dna
Human DNA

Valairat Dhamcharee, M.D.

genetic dna variants
Genetic (DNA) Variants
  • Each of us is different because we carry a unique combination of genetic variants.
  • These DNA variants have been analyzed and found that some of these DNA variants affect our risk of developing diseases, such as cancer, heart attack and diabetes.

Valairat Dhamcharee, M.D.

dna variants snps
DNA Variants = SNPs
  • A SNP, pronounced “snip”, is a single variation in the nucleotide sequence of DNA and stands for Single Nucleotide Polymorphism that can affect our inherited risk and a multitude of other characteristics.

Valairat Dhamcharee, M.D.

dna variants snps1
DNA Variants (SNPs)

Valairat Dhamcharee, M.D.

dna variants snps2
DNA Variants (SNPs)

Valairat Dhamcharee, M.D.

genetic marker snp
Genetic Marker (SNP)
  • When a DNA variant is shown to be correlated with such a characteristic, this SNP can be referred to as a genetic marker for that disorder.

Valairat Dhamcharee, M.D.

personalized genetic test
Personalized Genetic Test
  • Your genetic profile can indicate your potential genetic risk
  • It is in your genetic makeup that you can discover your predisposition for various conditions and diseases.
  • Once you are aware of those conditions, taking preventive measures is the next logical step.

Valairat Dhamcharee, M.D.

goals of genetic markers analysis
Goals of Genetic Markers Analysis
  • Predictive
  • Preventive
  • Personalized

Valairat Dhamcharee, M.D.

how do we collect dna sample
How do we collect DNA sample?

Valairat Dhamcharee, M.D.

what happened to my dna
What happened to my DNA?
  • Labs will extract DNA from the cells found within saliva.
  • Analysis of DNA for SNPs.
  • The sample will be destroyed no more than 60 days after results are finalized.
  • DNA extract will be destroyed no more than one year from the most recently ordered report sample receipt date.
  • Request at any time that DNA be destroyed after testing

Valairat Dhamcharee, M.D.

results
Results
  • Available in 4-6 weeks

Valairat Dhamcharee, M.D.

what can you do if you have genetic risks
What can you do if you have genetic risks?
  • Supplements
  • Lifestyle change

Valairat Dhamcharee, M.D.

how do you know if i do the right thing
How do you know if I do the right thing?
  • Telomere test to measure telomere length

Valairat Dhamcharee, M.D.

how to prevent and follow the change results
How to prevent and follow the change results?
  • Genetic counseling for detail to prevent the disorders screened to be at risk
  • Follow the result by “Telomere test”

Valairat Dhamcharee, M.D.

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