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生物学. 第 15 回 愛は神経とホルモンに乗って. 和田 勝. 「愛」って何?. 定型行動( Fixed action pattern ). たとえば次の例を見てください。. 刺激と反応. 音、光、匂いなど. 外界からの刺激. 個体. 受容器. 中枢神経系. 効果器. 反応. いろいろな行動. ニューロンの数が増える. 脊髄と脳. ニューロンの数が増える. 中枢神経系(脊髄と脳)の中に介在ニューロンによる神経回路が、つくられるようになります。. 特定の神経回路が、定型的行動パターンに対応するようになります(たとえば、歩行運動)。. 定型行動の解発.

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和田 勝

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15



Fixed action pattern






Tinbergen




releaser

key stimuli


X




courtship behavior


oxytocin9


1909Dale


1953Vigneaud

SS

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-GlyNH2


16CysteinS-S



G


10 20 30 40 50 60

1 MEGALAANWS AEAANASAAP PGAEGNRTAG PPRRNEALARVEVAVLCLIL LLALSGNACV

61 LLALRTTRQK HSRLFFFMKHLSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV

121 VGMFASTYLLLLMSLDRCLA ICQPLRSLRR RTDRLAVLATWLGCLVASAPQVHIFSLREV

181 ADGVFDCWAV FIQPWGPKAY ITWITLAVYIVPVIVLAACYGLISFKIWQN LRLKTAAAAA

241 AEAPEGAAAG DGGRVALARV SSVKLISKAK IRTVKMTFIIVLAFIVCWTPFFFVQMWSVW

301 DANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHEL VQRFLCCSAS YLKGRRLGET

361 SASKKSNSSS FVLSHRSSSQ RSCSQPSTA

3p25



GG

G


CIP3/DAG

G

C

IP3/DAG

Ca2+


C

CDAGIP3


cell membrane

lipid bilayer




H

H-C-OH

H-C-OH

H-C-OH

H

O

R1-C

O-

O

R2-C

O-

O

R3-C

O-

HO

O H-C-O-C-R1

R2-C-O-C-H

H-C-O-C-R3

H O

+

R


HO

O H-C-O-C-R1

R2-C-O-C-H O

H-C-O-P-O-X

H O-

phospholipid

phosphatide

X=


OH

R1-C-O-C-H OCH3

H-C-O-P-O-CH2-CH2-N+-CH3

R2-C-O-C-H O-CH3

OH




lipid bilayer



C

IP3Ca2


OTGq/11IP3/DAG

Ca


Ca2





-


-


-

neurosecretion






NHK


NHK




Vole

I125

Monogamousprairie volemontane vole

ProNAS 89,5981-5985 (1992)


prairie vole

montane vole


amygdala




NHK




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