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The Science and Ethics of Stem Cell Research. Stem Cell Development Lesson 1. Totipotent : Can become any cell in body or placenta. Pluripotent: Can become any cell in body. Totipotent stem cells. Multipotent: Can become any cell within a specific germ layer or cell lineage.

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Stem Cell Development Lesson 1

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The Science and Ethics of

Stem Cell Research

Stem Cell Development

Lesson 1


Totipotent: Can become any cell in body or placenta

Pluripotent: Can become any cell in body

Totipotent

stem cells

Multipotent: Can become any cell within a specific germ layer or cell lineage

Multipotent: Can become any cell within a specific germ layer or cell lineage

Fate Decision

Pluripotent

stem cells

(3-5 days old)

Blastocyst

Embryonic stem cells come from inner cell mass of blastocyst.

Gastrulation (day 14) leads to

Primary Germ Cells

Endoderm (inner)gdigestive tract, resp. track

Mesoderm (middle)gbones, blood cells, heart

Ectoderm (outer)gskin, CNS

Gastrulation (day 14) leads to

Primary Germ Cells

Endoderm (inner)gdigestive tract, resp. track

Mesoderm (middle)gbones, blood cells, heart

Ectoderm (outer)gskin, CNS

Fate Decision

Fate Decision

Implantation

Implantation

An Overview of Early Developmentmodeled with Play-Dough

Fertilized egg

Multipotent


What your zygote might look like:


The Zygote


What your morula might look like:


Early Cell Division

Source: Florida Institute for Reproductive Science and Technologies


Four-cell stage2 days after fertilization

Source: Florida Institute for Reproductive Science and Technologies


Eight-cell stage3 days after fertilization

Courtesy: RWJMS IVF Program

Source: Florida Institute for Reproductive Science and Technologies


Morula 4 days after fertilization16 cells

Source: Florida Institute for Reproductive Science and Technologies


What your blastula (blastocyst) might look like:


Blastula5 days after fertilization

Source: Florida Institute for Reproductive Science and Technologies

Courtesy: RWJMS IVF Program


Five Day Embryo

http://www.nationalgeographic.com/ngm/


Blastula (Blastocyst)

This image has been released into the public domain.


What your gastrula might look like:


Sea Urchin Development

One Cell to Blastula Stage

  • http://www.luc.edu/depts/biology/dev/urchindv.htm

  • (courtesy of Dr. J. Hardin, Univ. of Wisconsin)

  • http://www.exploratorium.edu/imaging_station/gallery.php?Asset=celldiv&Category=seaurchins&Type=video


Early Mouse

Development

One Cell to Morula Stage


Early Human Development


Multipotent

This graphic has been released into the public domain


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