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DIFFUSE LIVER DISEASE

DIFFUSE LIVER DISEASE. Dr. Bengt Norén M. D, Med Lic. Dep. of Radiology and CMIV University Hospital Linköping. BN 20111207. BN 20111207. BN 20111207. Conventional Biopsy. Inflammation. Fibrosis grading – Biopsy F0- F4 ( Batts and Ludwig ) Grouped into : F0 – F2 F3 – F4.

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DIFFUSE LIVER DISEASE

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  1. DIFFUSE LIVER DISEASE Dr. Bengt Norén M. D, Med Lic. Dep. of Radiology and CMIV University Hospital Linköping BN 20111207

  2. BN 20111207

  3. BN 20111207

  4. Conventional Biopsy • Inflammation Fibrosis grading – Biopsy F0- F4 (Batts and Ludwig) Grouped into : F0 – F2 F3 – F4 • Fibrosis/cirrhosis • Steatosis • Fe BN 20111207

  5. Non Invasive Liver Biopsy ”NILB” 1.31 P MRS 2. DCE-MRI BN 20111207

  6. Fibrosis/cirrhosis ; 31 P MRS BN 20111207

  7. Fibrosis/cirrhosis ; 31 P MRS I Conc mM Anabolic charge (AC) : [PME] / ([PME] + [PDE]) Patients had a significant larger AC than the control subjects, 0.29 vs 0.16 (p  0.005). PME Pi ATPb PDE BN 20111207 Noren et al European Radiology,2005, 15(1), 148-157.

  8. Fibrosis/cirrhosis ; 31 P MRS II BN 20111207

  9. Fibrosis/cirrhosis ; 31 P MRS II AC Group BN 20111207

  10. Fibrosis/cirrhosis ; 31 P MRS II Degree of fibrosis predicted from AC P = 0.0097. Fisher’s exact test AC cut-off value of 0.27 showed a sensitivity of 93% and a specificity of 54 %. BN 20111207 Noren et al European Journal of Radiology, 2008, 66(2), 313-320

  11. Fibrosis/cirrhosis; DCE-MRI Can we identify and separate different stages of fibrosis by quantitatively measure the uptake of Gd-EOB-DTPA (Primovist)using DCE-MRI ? BN 20111207

  12. Fibrosis/cirrhosis; DCE-MRI Prospective study. • 38 patients ( 21 men, 17 women) • Pathological liver function tests • Liver biopsy BN 20111207

  13. Fibrosis/cirrhosis; DCE-MRI • 1.5 T MR (Achieva, Philips Medical Systems ) • T1-weighted 3D GRE (native, arterial and venous portal phase; 3, 10, 20 and 30 min) KHep – contrast uptake rate LSC_N10 and LSC_N20 LSC10 and LSC20 BN 20111207

  14. Fibrosis/cirrhosis; DCE-MRI BN 20111207

  15. NILB ”Multi parameter Q - MR approach” Biopsy MR techniques; • Inflammation ? • MRS - 31P • MRS - 1 H • DCE- MRI • MRE • T2/T2* • Diffusion • Fibrosis/cirrhosis • Steatosis • Fe BN 20111207

  16. BN 20100906

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