BMP6(206176_at)
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BMP6(206176_at). BMPR2(225144_at). ACVR2A(205327_at). Exprs 0 2 4 6 8 10 12. Exprs 0 2 4 6 8 10 12. Exprs 0 2 4 6 8 10 12.

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Figure 1

BMP6(206176_at)

BMPR2(225144_at)

ACVR2A(205327_at)

Exprs

0 2 4 6 8 10 12

Exprs

0 2 4 6 8 10 12

Exprs

0 2 4 6 8 10 12

MBC PPC BMPC MM HMCL

MBC PPC BMPC MM HMCL

MBC PPC BMPC MM HMCL

ACVR1(203935_at)

ACVR2B(236126_at)

BMPR1(213578_at)

Exprs

0 2 4 6 8 10 12

Exprs

0 2 4 6 8 10 12

Exprs

0 2 4 6 8 10 12

MBC PPC BMPC MM HMCL

MBC PPC BMPC MM HMCL

MBC PPC BMPC MM HMCL

Figure 1.

A1

A2


Figure 1

SMAD4(202527_at)

SMAD1(210993_at)

SMAD5(225219_at)

Exprs

0 2 4 6 8 10 12 14

Exprs

0 2 4 6 8 10 12 14

Exprs

0 2 4 6 8 10 12 14

MBC PPC BMPC MM HMCL

MBC PPC BMPC MM HMCL

MBC PPC BMPC MM HMCL

Figure 1.

A3


Figure 1

Figure 1.

BMP6

BMP6

BMP6

BMP6 stimulation

phosho-SMAD1,-5,-8

phosho-SMAD2

BMP6

Actin

B1

B2

B3

XG-10

XG-11

U266

B4

C

pMMC

SKMM2


Figure 1

Figure 2.

+ BMP6

Co

+ BMP6

+ heparin

U266

BMP6


Figure 1

Figure 3.

XG-1

XG-19

XG-11

U266

0.0 0.2 0.4 0.6 0.8 1.0

0.0 0.2 0.4 0.6 0.8 1.0

0.0 0.2 0.4 0.6 0.8 1.0

0.0 0.2 0.4 0.6 0.8 1.0 1.2

4

4

4

4

4

4

4

4

4

4

0

0

0

0

0

0

0

0

0

0

.00128

.00128

.00128

.00128

.00128

.00128

.00128

.00128

.00128

.00128

.8

.8

.8

.8

.8

.8

.8

.8

.8

.8

.0064

.0064

.0064

.0064

.0064

.0064

.0064

.0064

.0064

.0064

.032

.032

.032

.032

.032

.032

.032

.032

.032

.032

.16

.16

.16

.16

.16

.16

.16

.16

.16

.16

SKMM-2

OPM-2

LP-1

0.0 0.2 0.4 0.6 0.8 1.0

0.0 0.2 0.4 0.6 0.8 1.0

0.0 0.2 0.4 0.6 0.8 1.0 1.0 1.4

XG-13

XG-10

RPMI-8226

0.0 0. 0.4 0.6 0.8 1.0 1.2

0.0 0.2 0.4 0.6 0.8 1.0

0.0 0.2 0.4 0.6 0.8 1.0 1.2

A

3H-uptake

BMP6-concentration (µg/ml)


Figure 1

Figure 3.

6.6%

6.7 %

7.2 %

8.0 %

7.5 %

5.5 %

6.3 %

6.1 %

14.0 %

25.5 %

12.2 %

38.5 %

8.0 %

5.7 %

5.7 %

48 h

72 h

24 h

8 h

B

medium control

medium control

+ heparin

count

BMP6

38.5 %

BMP6

+ heparin

7.1 %

8.0 %

annexin V-FITC


Figure 1

Figure 3.

pMMC 2

pMMC 3

pMMC 1

*

*

*

*

*

*

Fraction of non-apoptotic MMC

*

*

*

*

*

*

*

BMP6-concentration (µg/ml)

BMP6 stimulation

Cleaved Caspase-8

Cleaved Caspase-9

Actin

C

D

SKMM-2


Figure 1

Figure 3.

Noggin

Noggin + 1 µg/ml BMP6

*

0.0 0.5 1.0 1.5 2.0

0.0 0.5 1.0 1.5

0 .032 .16 .8 4 20

0 BMP6 .032 .16 .8 4 20

Sclerostin

Sclerostin + 1 µg/ml BMP6

*

*

*

*

0.0 0.5 1.0 1.5 2.0 2.5

0.0 0.5 1.0 1.5 2.0 2.5

0 BMP6 .032 .16 .8 4 20

0 .032 .16 .8 4 20

E

3H-uptake

Inhibitor-concentration (µg/ml)


Figure 1

Figure 4.

0.1 0.2 0.3 0.4 0.5 0.6

tubule development

positive

negative

4

0.8

0.16

0.032

medium

BMP6-concentration (µg/ml)

A

Medium control

Positive control

Negative control

0.16 µg/ml

0.032 µg/ml

0.8 µg/ml

4 µg/ml

B


Figure 1

Figure 5.

OS HM-group

BMP6high

BMP6high

BMP6high

BMP6high

P=.02

BMP6low

BMP6low

BMP6low

BMP6low

EFS LR-group

EFS HM-group

A

OS LR-group

P=.03

B


Figure 1

Figure 5.

EFS

OS

P=.03

WBM-BMP6high

WBM-BMP6high

WBM-BMP6low

WBM-BMP6low

C


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