Cardiovascular Health. HEALTHY CARDIOVASCULAR SYSTEM. HEALTHY HEART. HEALTHY ARTERIES. HEALTHY BLOOD PRESSURE. Globally…. 17 million people die of cardiovascular disease each year.
Surveys show that most women are far more afraid of breast cancer than of cardiovascular disease (even though 1 in 30 women’s deaths is from breast cancer while 1 in 2.4 is from CVD
2002 Heart and Stoke Statistical Update, American Heart Association
Study Group: ~ 3000 persons dying of external causes
Atherosclerosis begins in childhood
By age 15, all subjects had atherosclerosis
McGill HC Jr, McMahan CA, Herderick EE, Zieske AW, Malcom GT, Tracy RE, Strong JP; Circulation 2002 Jun 11;105(23):2712-8. Comment in: Circulation. 2002 Jun 11;105(23):2696-8.
Zieske AW, Malcom GT, Strong JP. Natural history and risk factors of atherosclerosis in children and youth: the PDAY study. Pediatr Pathol Mol Med 2002 Mar-Apr;21(2):213-37
Strong JP, Zieske AW, Malcom GT. Lipoproteins and atherosclerosis in children: an early marriage? Nutr Metab Cardiovasc Dis 2001 Oct;11 Suppl 5:16-22
Estimated Direct and Indirect Costs of Cardiovascular Diseases and Stroke United States: 2002
2002 Heart and Stroke Statistical Update, American Heart Association
As recently as five years ago, most physicians would have confidently described atherosclerosis as a straight plumbing problem.
Scientific American May, 2002 pg. 48
The long held conception of how the disease develops turns out to be wrong.
Not a straight plumbing problem!
Inflammation fuels the development and progression of Atherosclerosis
Peter Libby Scientific American May 2002, p 47-55.
Habitual response to events as if they were life-threatening generates a repetitive stress/inflammatory response that may result in atherosclerosis
Black PH, Garbutt LD. Stress, inflamation and cardiovascular disease. J Psychosomatic Res 2002, 52, 1-23.
Infections can inflame arteries and lead to heart attacks
Six microbes associated with CVD risk
Herpes Simplex viruses 1 and 2
American College of Cardiology March 2000
Targeted Transfer Factor
Prevalence of probable food allergy
0.61% for peanut.
<0.27% for wheat
0.09% for cow's milk and egg
Main egg allergens are found in whites
Woods RK, Thien F, Raven J, Walters EH, Abramson M. Prevalence of food allergies in young adults and their relationship to asthma, nasal allergies, and eczema. Ann Allergy Asthma Immunol 2002 Feb;88(2):183-9
Anet J, Back JF, Baker RS, Barnett D, Burley RW, Howden ME. Allergens in the white and yolk of hen's egg. A study of IgE binding by egg proteins. Int Arch Allergy Appl Immunol 1985;77(3):364-71
“Magnesium deficiency has been shown to correlate with a number of chronic cardiovascular diseases, including hypertension, diabetes mellitus, and hyperlipidemia.”
Fox C, Ramsoomair D, and Carter C. South Med J 2001; 94(12) :1195-20. Abstract.
“The American diet is low in magnesium, and with modern water systems, very little is ingested in the drinking water.”
Innerarity S. Crit Care Nurs 2000; 23(2): 1-19. Abstract.
Allows blood vessels to relax not spasm
Required for metabolic efficiency
Deficiency leads to hypertrophy or enlargement of the heart
Magnesium is a NATURAL calcium channel blocker (1)
Stigson, L. and I. Kjellmer (1997). "Serum levels of MAGNESIUM at birth related to complications of immaturity." Acta Paediatr 86(9): 991-4.
Med Text refs
high blood pressure
enhancement of inflammation
reduced blood clotting
Saari JT and Schuschke DA. Biofactors 1999; 10(4): 359-75.
of the vascular
during inflammatory conditions
such as atherosclerosis.
Hennig B, Meerarani P, et al. Br J Nutr 1999; 81(2): 85-6.
Both men and women who took zinc supplements had higher HDL cholesterol levels than non supplementing individuals.
Neggers YH, Bindon JR, et al. Biol trace Elem Res 2001; 79(1): 1-13.
Racek J, Holecek V, et al. Vnitr Lek 1999; 45(6): 373-8.
Miyazaki Y, Koyama H, et al. Nippon Koshu Eisei Zasshi 2001; 48(4): 243-57.
Zacarias-Castillo R, Hernandez-Rebollar AE, et al. Gac Med Mex 2001; 137(4): 335-45.
Ubbink JB, Becker PJ, Vermaak WJ. Nutr Rev 1996; 54(7): 213-6. Clarke R, Armitage J. Semin Thromb Hemost 2000; 26(3):341-8. Auer J, Berent R, et al. Wien Med Wochenschr 2001;151(1-2):25-8.
Antioxidants, such as vitamin C, may slow atherogenesis.
An increased intake of vitamin C is associated with a reduced risk of chronic diseases such as cancer, cardiovascular disease, and cataracts
Price KD, Price CS, et al. Atherosclerosis 2001; 158(1):1-12.
Carr AC and Frei B. Am J Clin Nutr 1999; 69(6): 1086-107.
-34% risk reduction
- 39% risk reduction
- 47% mortality reduction
- 47% infarct reduction
“Herpes group viruses, especially cytomegalovirus and herpes simplex virus type 1, have been associated with both atherosclerosis and restenosis.” (1)
L-Lysine monohydrochloride is used as a suppressant of recurrent herpes simplex infections. (2)
(1) Leinonen M, Saikku P. Scand Cardiovasc J 2000; 34(1): 12-20.
(2) Flodin, NW. J Am Coll Nutr 1997; 16(1): 7-21.
Nitric oxide is a relaxing factor
L-Arginine is the precursor for nitric oxide (NO).
Oral L-Arginine supplementation can improve symptoms of cardiovascular disease.
(Note: Magnesium is also critical.)
Wu G, Meininger CJ. J Nutr 2000; 130(11): 2626-9.
Boger RH, Bode-Boger SM. Annu Rev Pharmacol Toxicol 2001;41:79-99.
Promote nitric oxide production,
Inhibit platelet aggregation,
Increase high-density lipoprotein (HDL) cholesterol,
Bhat KPL, Kosmeder JW, 2nd. Antioxid Redox Signal 2001; 2(6): 1041-64.
Useful in congestive heart failure, angina pectoris, cardiomyopathy, coronary artery disease and in the preservation of myocardium.
Coenzyme Q10 is normally found in LDL cholesterol and it inhibits its oxidation.
Cardiac levels of Coenzyme Q10 were decreased in heart disease.
Singh RB, Niaz MA, et al. J Assoc Physicians India 1998; 46(3): 299-306.
Kucharska J, Gvozdjakova A, et al. Bratisl Lek Listy 1996; 97(6): 351-4.
LDL cholesterol, and
total triacylglycerol concentrations
“Provides a new, novel, food-based approach to lowering cholesterol in the general population.”
Heber D, Yip I, et al. Am J Clin Nutr 1999; 69(2): 231-6.