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Patrick An Introduction to Medicinal Chemistry 3/e Chapter 22 ANTIULCER AGENTS

Patrick An Introduction to Medicinal Chemistry 3/e Chapter 22 ANTIULCER AGENTS Part 2: Helicobacter pylori. Contents Part 2: Helicobacter pylori 21. Features of H. pylori (3 slides) 22. Treatment of H. pylori [5 slides]. 21. Features of H. pylori. Spiral, curved bacterium

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Patrick An Introduction to Medicinal Chemistry 3/e Chapter 22 ANTIULCER AGENTS

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  1. Patrick An Introduction to Medicinal Chemistry 3/e Chapter 22 ANTIULCER AGENTS Part 2: Helicobacter pylori

  2. Contents Part 2: Helicobacter pylori 21. Features of H. pylori (3 slides) 22. Treatment of H. pylori [5 slides]

  3. 21. Features of H. pylori • Spiral, curved bacterium • Grows best in oxygen concentrations of 5% • Naturally present in the stomachs of many people • Attaches to a sugar molecule on the surface of the cells lining the stomach wall • The organism secretes proteins and toxins that inflame the stomach lining • Responsible for the recurrence of esters • The organism is protected by the mucus layer • A pH gradient across the mucus layer means that the pH is near neutral at the stomach lining

  4. Stomach contents pH = 2 Mucus layer pH = 4 H . p y l o r i pH = 7 21. Features of H. pylori

  5. 21. Features of H. pylori • Bacterium produces urease enzyme • Neutralises any acid in the local environment

  6. Amoxicillin Metronidazole Omeprazole 22. Treatment of H. pylori • Triple therapy of a proton pump inhibitor and two antibiotics • Antibiotics work better at a higher pH than is normally present in stomach • The proton pump inhibitor is present to raise the pH • Example

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