GENES and TOBACCO USE. CAN GENES PREDICT WHO WILL…. develop heart disease? develop lung cancer? become a smoker? be able to quit?. FACTORS CONTRIBUTING to TOBACCO USE. Environment Tobacco advertising Conditioned stimuli Social interactions. Physiology Genetic predisposition
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Adoption studies compare the similarities between
- OR -
Correlations between relatives for average
reported cigarette consumption
Eysenck HJ, 1980.
Twin studies compare the similarities between
Concordant or discordant?
Higher concordance of tobacco use
for identical than for fraternal twins
Estimated heritability for smoking = 0.53
Linkage studies of smoking
Dopamine Reward Pathway
Reprinted with permission, Benowitz et al. (1994).
If genetic tests become available, should society encourage genetic testing for tobacco dependence?
Improved treatment for tobacco dependence?