Lyme Disease and The Lyme Disease Vaccine. Presentation By Jason Hadrath. Characterized by inflammation of:. 1. connective tissue (skin and joints). 2. nervous tissue. 3. cardiac tissue. What is Lyme Disease?. A multisystem inflammatory disease.
Lyme Disease and The Lyme Disease Vaccine
1. connective tissue (skin and joints)
2. nervous tissue
3. cardiac tissue
BEST POINT FOR TREATMENT !!
40 % of lyme cases are asymptomatic in the early stages.
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Developed by SmithKline Beecham Biologicals.
Given in three doses. Two doses, one month apart and again in 12 months.
Consisting of the complete lipoprotein OspA and aluminum hydroxide (adjuvant).
$ 8500 per shot.
Expressed in E. coli strain AR58.
Transformed with plasmid pOA15.
With OspA (a plasmid gene) as its insert.
The lipid moiety was added post-translationaly
An injection of OspA results in the formation of anti-OspA antibodies.
These antibodies possess bactericidal activity.
Antibodies taken in along with tickís bloodmeal.
B. burgdorferi destruction ensues.
Here is the key !
10,000 person study.
49% effective after two doses.
After three doses 100% effective in preventing asymptomatic infection.
Lack of long term testing.
Is a booster dose needed?
OspA contains a sequence that is similar to the human protein LFA-1.
This could lead to an autoimmune disease.
Biddle, W. Afield Guide to Germs. New Jeresy: Doubleday Publishing Groupe,1995.
Ginsberg, H.S. Ecology and Environmental Management of Lyme Disease. New Jersey: Rutgers University Press, 1993.
Lang, D. Coping with Lyme Disease. New York: Henery Holt and Company, 1993.
Silverstein, A. Lyme Disease the Great Imitator. New Jersey: Avstar Publishing Corp., 1990.
ìImmunization Against Lyme Disease - An Important First Step.î The New England Journal of Medicine July 23,1998: 263-264.
Marwick, C. ìGuarded Endorsement for Lyme Disease Vaccine.î JAMA June 24, 1998: 1937-1938.
Sigal, L.H. ìA vaccine consisting of Recombinant Bb OspA to Prevent Lyme disease.î The New England Journal of Medicine July 23,1998: 216-221.
Steere, A.C. ìVaccination Against LD with Recombinant Bb OspA with Adjuvant.î The New England Journal of Medicine July 23, 1998: 209-214.
Telford S.R. ìEfficancy of LD Vaccine Formulations in a Mouse Model.î The Journal of Infectious Diseases May, 1995: 1368-1370.
Sanz C. ìSummer of Danger.î Discover May, 1999: 64-71.
http://www.lymerix.com SmithKline Beecham Bio.
http://www.aldf.com American Lyme Disease Foundation, Inc.
http://www.uri.edu/ticklab The Tick Research Lab.
hppt://www.ent.iastate.edu/imagega Iowa State Entomolgy Image Gallery.
http:www.acponline.org/lyme American Academy of Physicians
http://www.cdc.gov/ncidod/dvbid/lymeinfo.htm Centers for Disease Control and Prevention.
http://thetick.powertie.org Brandons Tribute to the Tick.
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