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PED 105: ANATOMY & PHYSIOLOGY I PowerPoint PPT Presentation


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PED 105: ANATOMY & PHYSIOLOGY I. Barbara J. Engebretsen Assistant Professor, HPLS. Terminology. Anatomy Physiology. STRUCTURE & FUNCTION. “Design & Job” “Wings” “Scaffolding” “Molecular Motors”. HOMEOSTASIS.

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PED 105: ANATOMY & PHYSIOLOGY I

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PED 105: ANATOMY & PHYSIOLOGY I

Barbara J. Engebretsen

Assistant Professor, HPLS


Terminology

  • Anatomy

  • Physiology


STRUCTURE & FUNCTION

  • “Design & Job”

    • “Wings”

    • “Scaffolding”

    • “Molecular Motors”


HOMEOSTASIS

  • Maintaining Life and Health demands an ability to respond to constant disruptions of our internal environment

  • The Goal of Homeostasis is to maintain a constant internal environment


HOMEOSTASIS

  • Healthy Balance

  • “Set Point”

  • Negative feedback


QUESTIONS:

  • What is our “internal environment”?

  • What are some conditions of that environment that must be regulated and maintained?


ANSWERS:

  • Water!! A 70 kg adult is about 41 liters of H2O: ~8-9% of our body weight


Watery Conditions: Key Variables

  • Temperature

  • pH (H+ and OH-)

  • O2/CO2

  • Solutes: NaCl, K+, Ca++...

  • Nutrients


And More...

  • Waste Products

  • Volume

  • Compartment


Key Terms: Homeostasis

  • Set Point

  • Negative Feedback

    • Sensor (Receptor)

    • Control Center (911!)

    • Signal Transduction

    • Effector


Another Question:

  • After donating blood, what do you predict will happen to heart rate?

  • WHY?


Think about:

  • What is the “set point” condition?

  • What are the “receptors”?

  • What is the control center?

  • What is the “effector”?

    • This is Negative Feedback!


What if the negative feedback sequences FAIL to return blood pressure to normal?

This is BAD:

Hypovolemic Shock is a failure of Negative Feedback. Shock is Fatal.


Pathology: Disease

  • Failure of Negative Feedback or worse:

  • Positive Feedback

  • Positive Feedback exceptions: parturition, ovulation


Homeostasis Lab:

  • Take 10: Read the Lab

  • Record you pulse: Sit quietly, recording HR for 15 seconds.

  • Wait 15 seconds, then repeat

  • Take 10 readings

  • Multiply your HR by 4 to get minute heart rates


Calculations:

  • Calculate your average HR: round off to whole number

  • Graph your average by drawing a red line at that value

  • Plot each of your readings on the graph


Advanced Thinking:

  • Calculate the Standard Deviation of your average HR

    • How “tightly” is your HR controlled?

  • Find out that average HR for exercisers vs. non-exercisers

    • Did our data match your hypothesis?


Summary

  • Define Anatomy/Physiology

  • Structure/Function Relationships

  • Homeostasis: Negative and Positive Feedback


Assignment:

  • Read: Chapter 1:1-9

  • Outline sturctural/functional organization (p. 2-3)

  • Turn in Homeostasis lab


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