Ped 105 anatomy physiology i
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PED 105: ANATOMY & PHYSIOLOGY I. Barbara J. Engebretsen Assistant Professor, HPLS. Terminology. Anatomy Physiology. STRUCTURE & FUNCTION. “Design & Job” “Wings” “Scaffolding” “Molecular Motors”. HOMEOSTASIS.

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PED 105: ANATOMY & PHYSIOLOGY I

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Ped 105 anatomy physiology i

PED 105: ANATOMY & PHYSIOLOGY I

Barbara J. Engebretsen

Assistant Professor, HPLS


Terminology

Terminology

  • Anatomy

  • Physiology


Structure function

STRUCTURE & FUNCTION

  • “Design & Job”

    • “Wings”

    • “Scaffolding”

    • “Molecular Motors”


Homeostasis

HOMEOSTASIS

  • Maintaining Life and Health demands an ability to respond to constant disruptions of our internal environment

  • The Goal of Homeostasis is to maintain a constant internal environment


Homeostasis1

HOMEOSTASIS

  • Healthy Balance

  • “Set Point”

  • Negative feedback


Questions

QUESTIONS:

  • What is our “internal environment”?

  • What are some conditions of that environment that must be regulated and maintained?


Answers

ANSWERS:

  • Water!! A 70 kg adult is about 41 liters of H2O: ~8-9% of our body weight


Watery conditions key variables

Watery Conditions: Key Variables

  • Temperature

  • pH (H+ and OH-)

  • O2/CO2

  • Solutes: NaCl, K+, Ca++...

  • Nutrients


And more

And More...

  • Waste Products

  • Volume

  • Compartment


Key terms homeostasis

Key Terms: Homeostasis

  • Set Point

  • Negative Feedback

    • Sensor (Receptor)

    • Control Center (911!)

    • Signal Transduction

    • Effector


Another question

Another Question:

  • After donating blood, what do you predict will happen to heart rate?

  • WHY?


Think about

Think about:

  • What is the “set point” condition?

  • What are the “receptors”?

  • What is the control center?

  • What is the “effector”?

    • This is Negative Feedback!


What if the negative feedback sequences fail to return blood pressure to normal

What if the negative feedback sequences FAIL to return blood pressure to normal?

This is BAD:

Hypovolemic Shock is a failure of Negative Feedback. Shock is Fatal.


Pathology disease

Pathology: Disease

  • Failure of Negative Feedback or worse:

  • Positive Feedback

  • Positive Feedback exceptions: parturition, ovulation


Homeostasis lab

Homeostasis Lab:

  • Take 10: Read the Lab

  • Record you pulse: Sit quietly, recording HR for 15 seconds.

  • Wait 15 seconds, then repeat

  • Take 10 readings

  • Multiply your HR by 4 to get minute heart rates


Calculations

Calculations:

  • Calculate your average HR: round off to whole number

  • Graph your average by drawing a red line at that value

  • Plot each of your readings on the graph


Advanced thinking

Advanced Thinking:

  • Calculate the Standard Deviation of your average HR

    • How “tightly” is your HR controlled?

  • Find out that average HR for exercisers vs. non-exercisers

    • Did our data match your hypothesis?


Summary

Summary

  • Define Anatomy/Physiology

  • Structure/Function Relationships

  • Homeostasis: Negative and Positive Feedback


Assignment

Assignment:

  • Read: Chapter 1:1-9

  • Outline sturctural/functional organization (p. 2-3)

  • Turn in Homeostasis lab


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