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PED 105: ANATOMY & PHYSIOLOGY I. Barbara J. Engebretsen Assistant Professor, HPLS. Terminology. Anatomy Physiology. STRUCTURE & FUNCTION. “Design & Job” “Wings” “Scaffolding” “Molecular Motors”. HOMEOSTASIS.

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Ped 105 anatomy physiology i

PED 105: ANATOMY & PHYSIOLOGY I

Barbara J. Engebretsen

Assistant Professor, HPLS


Terminology
Terminology

  • Anatomy

  • Physiology


Structure function
STRUCTURE & FUNCTION

  • “Design & Job”

    • “Wings”

    • “Scaffolding”

    • “Molecular Motors”


Homeostasis
HOMEOSTASIS

  • Maintaining Life and Health demands an ability to respond to constant disruptions of our internal environment

  • The Goal of Homeostasis is to maintain a constant internal environment


Homeostasis1
HOMEOSTASIS

  • Healthy Balance

  • “Set Point”

  • Negative feedback


Questions
QUESTIONS:

  • What is our “internal environment”?

  • What are some conditions of that environment that must be regulated and maintained?


Answers
ANSWERS:

  • Water!! A 70 kg adult is about 41 liters of H2O: ~8-9% of our body weight


Watery conditions key variables
Watery Conditions: Key Variables

  • Temperature

  • pH (H+ and OH-)

  • O2/CO2

  • Solutes: NaCl, K+, Ca++...

  • Nutrients


And more
And More...

  • Waste Products

  • Volume

  • Compartment


Key terms homeostasis
Key Terms: Homeostasis

  • Set Point

  • Negative Feedback

    • Sensor (Receptor)

    • Control Center (911!)

    • Signal Transduction

    • Effector


Another question
Another Question:

  • After donating blood, what do you predict will happen to heart rate?

  • WHY?


Think about
Think about:

  • What is the “set point” condition?

  • What are the “receptors”?

  • What is the control center?

  • What is the “effector”?

    • This is Negative Feedback!


What if the negative feedback sequences fail to return blood pressure to normal

What if the negative feedback sequences FAIL to return blood pressure to normal?

This is BAD:

Hypovolemic Shock is a failure of Negative Feedback. Shock is Fatal.


Pathology disease
Pathology: Disease pressure to normal?

  • Failure of Negative Feedback or worse:

  • Positive Feedback

  • Positive Feedback exceptions: parturition, ovulation


Homeostasis lab
Homeostasis Lab: pressure to normal?

  • Take 10: Read the Lab

  • Record you pulse: Sit quietly, recording HR for 15 seconds.

  • Wait 15 seconds, then repeat

  • Take 10 readings

  • Multiply your HR by 4 to get minute heart rates


Calculations
Calculations: pressure to normal?

  • Calculate your average HR: round off to whole number

  • Graph your average by drawing a red line at that value

  • Plot each of your readings on the graph


Advanced thinking
Advanced Thinking: pressure to normal?

  • Calculate the Standard Deviation of your average HR

    • How “tightly” is your HR controlled?

  • Find out that average HR for exercisers vs. non-exercisers

    • Did our data match your hypothesis?


Summary
Summary pressure to normal?

  • Define Anatomy/Physiology

  • Structure/Function Relationships

  • Homeostasis: Negative and Positive Feedback


Assignment
Assignment: pressure to normal?

  • Read: Chapter 1:1-9

  • Outline sturctural/functional organization (p. 2-3)

  • Turn in Homeostasis lab


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