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Human calcitonin

Human calcitonin. Drugbank ID : DB06773. Description :

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Human calcitonin

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  1. Human calcitonin Drugbank ID : DB06773

  2. Description: Calcitonin is a 32-amino acid linear polypeptide hormone that is produced in humans primarily by the parafollicular cells (also known as C-cells) of the thyroid, and in many other animals in the ultimobranchial body. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). It has been found in fish, reptiles, birds, and mammals. Its importance in humans has not been as well established as its importance in other animals, as its function is usually not significant in the regulation of normal calcium homeostasis. Calcitonin was extracted from the Ultimobranchial glands (thyroid-like glands) of fish, particularly salmon. Salmon calcitonin resembles human calcitonin, but is more active. At present, it is produced either by recombinant DNA technology or by chemical peptide synthesis. The pharmacological properties of the synthetic and recombinant peptides have been demonstrated to be qualitatively and quantitatively equivalent.

  3. Drug interaction : The serum concentration of lithium can be decreased when it is combined with human calcitonin. Human calcitonin may increase the hypocalcemic activities of Zolendronic acid.

  4. References: http://www.drugbank.ca/drugs/DB06773

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