DeltaNu – What’s New in 06

1. DeltaNu – What’s New in 06 Keith Carron, CEO Swift Tour Casper, WY September 13, 2006

2. Teaching --Research Portable -- Analysis

3. 2006 Improving the product line Advantage Series Standard – 2 mW HeNe laser Now 100 mW @ 532 nm, 120 mW @ 785 nm, 200 mW @ 808 nm. Inspector Series Standard – 75 mW 785 nm Now 120 mW at 785 nm with an externally coupled stabilizer. This makes product to product reproducibility extremely high. It enables library technology.

4. Adding Value to Existing Products

5. Oscar for Inventors RockHound Something New Out of Something Old • This year – • Getty Museum Purchased • Detroit Art Institute (Ordered) • Instrumentación Específica de Materiales (Order in process) • New York Metropolitan (Requested) • University of Arizona – 1000 + Mineral Library. DeltaNu at the Louvre

6. Pull of New Markets -- Pushing New Technology Brand Security Counterfeiting Homeland Security Point-of-Care ReporteR Cell Phone Technology Compact Memory Optical Information Storage Photonic Crystals

7. Long Pass Filter Diffraction Grating TM ReporteR Beamsplitter Collection Lens <Laser Raman> Sample Notch Filter Focusing Lens Diode Laser Array Detector + - CPU Raman Transducer Cyclohexane Not Cyclohexane -- Taking Raman to the Limit Main Entry: trans·duc·erFunction: noun: a device that is actuated by power from one system and supplies power usually in another form to a second system <a loudspeaker is a transducer that transforms electrical signals into sound energy>

8. I(ν) dI/dν Regions of correlation Region of no information 500 1000 1500 2000 2500 Brand Security Proprietary Raman Ink How does it work? Material Identification through Raman spectroscopy. Libraries of Raman Barcodes Anti-counterfeiting Wavenumbers

9. Hanna Basin Amber Age Dependent Peaks C=O Modern Pine Resin 600 1000 1400 1800 Wavenumbers Hanna Basin Amber – Amber varies greatly with location and age. The Hanna Basin in south-centralWyoming contains a combined thickness of roughly 11.5 km of Upper Cretaceous and Paleocene strata. Raman spectroscopy provides a large amount of information about amber. This study shows the age dependent 1650 cm-1 C=C feature relative to the 1450 cm-1 C-H scissor modes. The ExamineR also clearly shows the carbonyl features due to oxidation and esterification. Modern pine resin is show for comparison. Modern pine resin does not show oxidation products and has a relatively large intensity ratio of the 1650 cm-1 features to the 1450 cm-1 band. For more on Raman spectroscopy of amber see: Brody, R., Edwards, H.G.M., and Pollard, A., A study of amber and copal samples using FT-Raman spectroscopy, Spectrochemica Acta A, 57, 2001, p. 1325 – 1338. 2006 -- Taking advantage of our uniqueness Free-space DeltaNu module 785 nm or 532 nm

10. Wavenumbers Lichen induced changes in feldspar? -- This feldspar sample was found in the Sherman granite deposits east of Laramie, WY. When examined with DeltaNu’s Raman microscope a freshly cleaved sample shows symmetric T-O stretches and O-T-O deformations indicative of a K-feldspar (Microcline). The same specimen shows peak shifts of +7 cm-1 for the 478 cm-1 peak and -3 cm-1 for the 515 cm-1 peak near lichen growths. These shifts are indicative of Ca-feldspar (Anorthite). For more on Raman spectroscopy of feldspars see: http://epsc.wustl.edu/haskin-group/Raman/feldspar.htm 400 550 High-end Research Grade Raman Microscope Released this year – The ExamineR uses our unique free-space design. Competitors place a microscope on their Raman systems; we place our Raman system on a microscope. This produces greatly smaller footprints and very high sensitivity.

11. 1.0 DeltaNu LLC, LARAMIE, WINS DARPA PHASE II Congratulations to DeltaNu in Laramie on their recent DARPA Phase II award! Project Title: Miniature Long-Range Stand-off ImagingRaman System for Detection of Biological Materials Principle Principle Investigator: Keith CarronEmail:keith@deltanu.comAward: $750,000Non-Technical Summary: An urgent national defense need is the ability to detect WMD chemical and biological agents and improvised explosive devices (IED) at a distance with high sensitivity and specificity. The goal of this DARPA Phase II STTR project is the development of a prototype hand-held telescopic Raman spectroscopy system capable of sensitive, high-specificity, stand-off identification of chemical (including IED explosives)and biological materials at distances of up to one kilometer, dependent upon "seeing" conditions. Among the issues addressed by this development are signal interferences from sunlight, fluorescence and other out-of-phase sources of noise. Eye safety issues are also addressed. This development will lead to a number of commercialization opportunities, especially in multiplexed bio-assay and hazmat chemical identification at long distances. Additional information about DeltaNu can be found on their web site: www.deltanu.com Crescent Diagnostics and DeltaNu Ink IP Agreement July 18th - Limerick, Ireland and Laramie, Wyoming USA Crescent Diagnostics Ltd. has signed an intellectual property option agreement with DeltaNu LLC. This agreement gives Crescent an exclusive option to develop and market products from intellectual property that was invented at the University of Limerick and the University of Wyoming and is jointly held by Crescent and DeltaNu. The intellectual property describes a novel way to use Raman spectroscopy to diagnose bone health conditions like osteoporosis. The terms of the agreement were not disclosed. "We are very happy to conclude an agreement like this - it formalizes a great working relationship we've had with DeltaNu for the past two years," says Ernest Poku, CEO of Crescent Diagnostics. "The applications for Raman spectroscopy are growing," says Dr. Keith Carron, CEO of DeltaNu, "and DeltaNu is fortunate to partner with a leader like Crescent as it brings this important technology to the market." About Crescent Diagnostics Ltd: Crescent Diagnostics Ltd was established in 2004 to develop and commercialize a bone quality test based on Raman technology. Crescent Diagnostics conducts research at its offices in Limerick, Ireland and maintains a corporate office in London, UK. The company is runby an experience medical diagnostics management team. For more information about Crescent Diagnostics, please visit the website at www.crescentds.com.

12. Hypothesis – Osteoporosis is a disease of bone protein and bone protein health is exhibited through fingernails CH2 CH2 Bending S-S 3 4 S-S 3 2 2 1 1 500 500 1000 1000 1500 1500 2000 2000 Wavenumbers [(I(2) – I(1)]/[I(4) – I(3)] 0.25 136 – O 160 – O 202 – H 216 – H 0.2 0.15 0.1 0.05 0 216 136 160 202 Patient

13. 2006 -- Thinking Big – DeltaNu is on 6 Continents France Serlabo Technologies sarl1914. Route d'Avignon84320 Entraigues sur drawer SorgueFranceinfo@serlabo.fr+33 (0)4 90 23 77 20 Malaysia InterscienceNo. 2, Jalan Sungai Kayu Ara 32/38Berjaya Industrial Park40460 Shah AlamSelangor Darul Ehsan, Malaysiawww.its-interscience.cominfo@its-interscience.com+603-57409888 Singapore ITS Scientific & Medical219 Henderson Road, #11-02Henderson Industrial Park, Singapore 159556www.its-sciencemedical.cominfo@its-sciencemedical.com+65-6273 0898 China ITS Science (China)Shanghai Office 05-06 Rooms, 17F 2025 LaneYong Sheng Building, Zhongshan RoadShanghai, China 200235www.its-china.com.cninfo@its-science-china.com+86-21-64814428 Korea Young In Scientific Co.,Ltd.547 Kang Nam-KuShin Sa-DongSeoul, 135-890, Koreawww.youngin.com82-2-519-7300 Netherlands Beun De RondePostbus 1371390 AC AbcoudeThe Netherlandswww.beunderonde.nlinfo@beunderonde.nl+31 (0)294 280 980 Thailand Thailand Office (ITS Thailand)Bangkok Tower, Unit 909, 9th Floor, 2170New Petchburi Road, Bangkapi, HuaykwangBangkok 10320, Thailandwww.its-thailand.cominfo@its-thailand.com+66-2-308 0611 Indonesia ITS IndonesiaJalan Bukit Gadong Raya, Blok D No. 9Kompleks Grading Bukit IndahJakarta Utara 14240, Indonesiawww.its-indonesia.cominfo@its-indonesia.com+62-21-451 6222 Vietnam VNITS44 Nguyen Thi Minh KhaiDa Kao Ward, District 1HoChiMinh City, Vietnamwww.its-vietnam.cominfo@its-vn.com+84-8-822 9865 Belgium Beun - de Ronde Serlabo (BRS) B.V.B.A.Steenweg op Ruisbroek 290B-1620 DrogenbosBelgiumwww.brs.beinfo@brs.be+32 (0)2 334 22 70 South Africa Elabtec31 Fettes RoadPort Elizabeth, South Africawww.elabtec.co.zaelabtec@elabtec.co.za+27 (0)41 3733303

14. Tony Nevshemal, COO Rebekah Peifer, Office Manger Shane Buller, Senior Engineer Katie Keeney, Office Assistant Branden Phillips, Production Manager Keith Carron, CEO Rick Cox, VP Sales and Marketing Gene Watson, Business Advisor George Lucy, Production Associate Mark Watson, Design Engineer Phillip Duran, Production Assistant Not Pictured: Minden Shuster, Marketing Associate Matt Russell, Mechanical Engineer Travis Thompson, Applications Scientist Wyoming Graduates

15. Acknowledgements • SBIR – Over $4,000,000 in startup funds • National Science Foundation • National Institutes of Health • Department of Energy • United States Department of Agriculture • DARPA • WSSI Phase 0 • Wyoming Business Council • Wyoming Trade Show Incentive Grant • Work-Force Development Assistance • CDBG Assistance with Facility • WTBC • University of Wyoming • SBDC • Manufacturing Works • Research Product Center