ALZHIEMERS DISEASE IN UK ‘’The Dementia Time bomb’’. By VISHAL ZAVERI AND ORE AJAI. What is Alzheimer's disease ?. Dementia= death of neuronal cells in the brain causing memory loss. Some forms are reversible and some are irreversible
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ALZHIEMERS DISEASE IN UK
‘’The Dementia Time bomb’’
By VISHAL ZAVERI AND ORE AJAI
Causing loss of
820,000 cases of dementia in UK
450,000 cases are Alzhiemer’s
Financial cost is over £23bn pa, that is twice that of cancer, three times the impact of heart disease and four times that of stroke
Men, Women and all racial, economic and social groups are affected.
AD is not natural for ageing
it is pathological!
Youngest age- 28 years
Described by AloisAlzhiemer’s- 105 years ago
Still nothing has been done !
Stages and Symptoms
Thinking & Planning
Speaking and understanding
Learning and STM memory
Whole cortex is damaged
Familial AD- causing early onset AD – mutations in APP gene(chr21), OR presenilin genes(PSEN-1 (chr14) OR PSEN-2(chr1). Late onset- APOE-4 (everyone has one copy).
Down Syndrome- both mutations for APP and DS- tend to always get AD at 40yrs.
Head injuries with loss of consciousness= *3 Depression
Ingestion of Aluminium salts MCI
Mother’s age at your birth Diabetes
PET scan-glucose metabolism
Aricept, Exelon(patch), Razadyne
Namenda for severe AD