ALZHIEMERS DISEASE IN     UK
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ALZHIEMERS DISEASE IN UK ‘’The Dementia Time bomb’’. By VISHAL ZAVERI AND ORE AJAI. What is Alzheimer's disease ?. Dementia= death of neuronal cells in the brain causing memory loss. Some forms are reversible and some are irreversible

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ALZHIEMERS DISEASE IN UK ‘’The Dementia Time bomb’’

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Alzhiemers disease in uk the dementia time bomb

ALZHIEMERS DISEASE IN UK

‘’The Dementia Time bomb’’

By VISHAL ZAVERI AND ORE AJAI


What is alzheimer s disease

What is Alzheimer's disease?

  • Dementia= death of neuronal cells in the brain causing memory loss. Some forms are reversible and some are irreversible

  • Alzheimer's disease: progressive neuronal cell death deteriorating all regions of the brain stopping physical and mental functioning. (3-20 yrs+)

    Causing loss of

  • Memory

  • Cognitive functioning

  • Speech

  • Vision

  • Ultimately leading to death!


Epidimeology

Epidimeology

820,000 cases of dementia in UK

450,000 cases are Alzhiemer’s

Financial cost is over £23bn pa, that is twice that of cancer, three times the impact of heart disease and four times that of stroke

Men, Women and all racial, economic and social groups are affected.

AD is not natural for ageing

it is pathological!

Youngest age- 28 years


Proposed pathogenesis

Proposed Pathogenesis

Described by AloisAlzhiemer’s- 105 years ago

Still nothing has been done !


Alzhiemers disease in uk the dementia time bomb

Stages and Symptoms

Early Alzheimer's

Moderate

Thinking & Planning

SENSES

Speaking and understanding

Learning and STM memory

severe

Whole cortex is damaged

LTM affected


Risk factors

Risk factors

  • Genetic Factors- rare

    Familial AD- causing early onset AD – mutations in APP gene(chr21), OR presenilin genes(PSEN-1 (chr14) OR PSEN-2(chr1). Late onset- APOE-4 (everyone has one copy).

    Down Syndrome- both mutations for APP and DS- tend to always get AD at 40yrs.

    Environmental Other

    Head injuries with loss of consciousness= *3 Depression

    Ingestion of Aluminium salts MCI

    Countryside Obesity

    Mother’s age at your birth Diabetes


Diagnosis

Diagnosis

PET scan-glucose metabolism


Treatment

Treatment

  • Incurable but symptoms can be managed

Cholinesterase inhibitors

Aricept, Exelon(patch), Razadyne

Glutamate regulator

Namenda for severe AD


Current research

Current research

Current Research

  • Researchers in 2013 studied mice and found that after administering mice with Alzhiemer’s disease, neuronal cell death stopped!

  • However side effects were ample!

  • Latest drug failure- Gammagard


References

References

  • http://medicineworld.org/cancer/lead/7-2007/symptoms-of-severe-alzheimers-disease.html

  • http://www.ctvnews.ca/health/alzheimer-s-researchers-say-they-are-undeterred-by-latest-drug-failure-1.1297965

  • http://www.alz.org/alzheimers_disease_1973.asp

  • http://www.triumf.ca/research-highlights/experimental-result/cutting-edge-alzheimers-research

  • http://www.alzheimersresearchuk.org/

  • http://www.brightfocus.org/alzheimers/about/understanding/plaques-and-tangles.html


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