Educational outreach in the vision lab
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Educational Outreach in the Vision lab. What is “educational outreach”?. Educational outreach... ...supports formal or classroom-based education ...supports informal education outside the classroom ...increases understanding and appreciation of science

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Educational Outreach in the Vision lab

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EducationalOutreach in the Vision lab

What is “educational outreach”?

Educational outreach...

  • ...supports formal or classroom-based education

  • ...supports informal education outside the classroom

  • ...increases understanding and appreciation of science

  • ...increases the involvement in science

Educational Outreach in our lab

  • Genomics Media Book

  • DESTINY Bus Module

Genomics MediaBook

  • interactive multimedia environment that contains realistic 3D Flash animations, bioinformatics tools, video and audio files, and an electronic reference almanac

  • can be a stand-alone content delivery system or a way to supplement science courses that cover genomic related materials.

  • primary audiences: science instructors and students in upper division natural science courses with knowledge of genetics.

  • collaboration of • Institute for Science Learning, UNC

    • Malcolm Campbell, Davidson College, NC

    • Center Line Productions, Raleigh, NC

Genomics MediaBook: 3 themes, 7 topics

pairwise sequence alignment,

multiple sequence alignment,

phylogenetic reconstruction


genome annotation


Sequence Analysis topic: content

  • pairwise sequence alignment


  • introduction

  • global vs. local

  • scoring matrices

  • dynamic programming


  • multiple sequence alignment



  • introduction

  • why DP won’t work

  • progressive methods

  • iterative methods

  • phylogenetic reconstruction



  • introduction

  • anatomy of a phylogeny

  • distance-based,

  • character-based

  • methods

  • NJ example

  • MP and ML (overview)

  • bootstrap

storyboard - example slide

storyboard - example slide

GMB beta

GMB: opportunities and challenges

  • great opportunity to be involved in the development of a new kind of textbook!

  • templates for different stages have yet to be worked out.

  • animations are not a natural way of thinking about lecture material for us - yet.

  • we have to write out the narration for the book.


PMABS (Partnership for Minority Advancement in the Biomolecular Sciences):

DESTINY promotes equity of access to quality science learning opportunities in order to increase interest, ensure understanding, and demonstrate the relevance of science to all students' lives.

Typical DESTINY module

  • Pre-lab (in class)

    activities to set up a story/question and to cover background necessary to carry out the wet-lab

  • Wet-lab (aboard DESTINY)

    discovery/answer: protein or gel electrophoresis

  • Post-lab (in class)

    discuss wet-lab, optional follow-up topics

The basis for our DESTINY module:

  • In 1905 Constantin Mereschkowsky was the first to argue that chloroplasts are (derived from) reduced cyanobacteria.

  • His errors (that students are going to find and correct)

    • he missed the dichotomy of life into prokaryotes and eukaryotes; he inferred that life arose twice independently

    • he did not recognize that mitochondria also are descendants of endosymbiotic bacteria

    • he thought that the different colored plastids of different algal groups arose from different free-living cyanobacteria

Our DESTINY module

  • Pre-lab

    students will learn about an “almost correct” hypothesis of endosymbiosis from 1905 and will come up with a strategy to test this hypothesis using 2004 tools

  • Computer-lab

    students will do sequence alignment and phylogeny reconstruction of mitochondrial, chloroplast, nuclear, and bacterial sequences to confirm mitochondrial and plastid endosymbiosis

  • Post-lab

    discuss wet-lab, optional follow-up topics

Our DESTINY module: pre-lab

Our DESTINY module: computer lab

Our DESTINY module: post-lab

  • some ideas:

  • primary vs. secondary endosymbiosis

  • organellar gene loss and gene transfer to the nucleus

  • origin of the nucleus

  • more on phylogenetic reconstruction

DESTINY: opportunities and challenges

  • DESTINY is great for high school kids who wouldn’t be able to use new technology otherwise

  • this will be a module for high school students!

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