INTERPRETATION OF BLOOD SUGAR VALUES

1. INTERPRETATION OF BLOOD SUGAR VALUES DR.V.SEKAR COIMBATORE DIABETES FOUNDATION

2. HYPERGLYCEMIA IS THE HALLMARKOF DIABETES HYPERGLYCEMIA IS THE HALLMARK OF DIABETES

3. HYPERGLYCEMIA IS THE HALLMARKOF DIABETES DIABETES TREATMENT IS BASED ON THE NUMBER IN MILLIGRAMS BEFORE WE DECIDE WHETHER BLOOD SUGAR IS NORMAL , HIGH OR LOW

4. HYPERGLYCEMIA IS THE HALLMARKOF DIABETES HOW THE BOOLD SUGAR IS DERIVED FROM WHERE,WHAT METHOD IS CRITICAL

5. HYPERGLYCEMIA IS THE HALLMARKOF DIABETES THE MOST CRITICAL ISSUE IS CLINICAL CORELATION BLOOD SUGAR SHOULD NOT BE TREATED THE PERSON WITH BLOOD SUGAR SHOULD BE TREATED

6. SOURCE OF BLOOD CAPILLARY OR VENOUS PLASMA WHAT METHOD? WHICH MACHINE? MANUAL,SEMI AUTOMATED, FULLY AUTOMATED

7. STEPS FOR INTERPRETATING BLOOD SUGAR VALUE • PRE ANALYSIS • ANALYSIS • POST ANALYSIS

8. PRE ANALYSIS • BLOOD COLLECTION • LABELLING • ANTI COAGULANT • CENTRIFUGE

9. BLOOD COLLECTION

10. ANTI COAGULANT

12. LABELLING

13. CENTRIFUGATION VIDEO

14. PLASMA

15. PIPETING 1 ML OF REAGENT 10 MICRO LITER OF PLASMA

16. TYPES OF MACHINE • TOTALLY MANUAL • SEMI AUTOMATED • FULLY AUTOMATED

17. ANALYSIS

18. TYPES OF TESTING GLUCOSE OXIDATES DEHYDROGENASE METHOD (GOD) HEXOKINASE METHOD

19. TYPE OF REAGENTS END POINT METHOD KINETIC METHOD

20. TESTING VIDEO

21. TIME OF TESTING BLOOD COLLECTION TIME TESTING TIME REPORT RELEASING TIME IS MORE IMPORTANT

22. EVERY ONE HOUR THERE IS A FALL OF 10 – 15 MILLIGRAMS

23. SAMPLE STORAGE ONLY FOR 24 HRS AT 2 – 8 DEGREE

24. POST ANALYSIS

25. REPORT RELEASING VERIFICATION RECHECKING CLINICAL CORRELATION

27. CALIBERATIONQUALITY CONTROL

28. WHY FASTING IS HIGH ? • Basal Insulin Deficiency: • Pre Dinner / Post Dinner Blood Sugar Abnormality: • CHO Load:  High Low Medium • Glycaemic Index:  High Low • Fibre Content of Food:  High Low Medium • Time of Food: Untimely Food Timely Food • Somyogi: • Dawn Phenomenon: • Medication: • Check Insulin Vial Clear Turbid Expiry Checked • Storage Area Refrigerator Room Temp • Check Syringe U 40 U100 • Check OHA Less dose Correct dose  High dose • Time of Insulin Correct Time Untime • Insulin Meal Mismatch:

29. WHY POST PRANDIAL IS HIGH ? • Basal Insulin Deficiency: • Pre Dinner / Post Dinner Blood Sugar Abnormality: • CHO Load:  High Low Medium • Glycaemic Index:  High Low • Fibre Content of Food:  High Low Medium • Time of Food: Untimely Food Timely Food • Somyogi: • Dawn Phenomenon: • Medication: • Check Insulin Vial Clear Turbid Expiry Checked Storage Area Refrigerator Room Temp • Check Syringe U 40 U100 • Check OHA Less dose Correct dose •  High dose • Time of Insulin Correct Time Untime • Insulin Meal Mismatch:

30. PERSISTANTLY A1C • Diet factor: • High CHO Load Glycaemic index  High, Low Fibre content of the food  High, Low, Medium Time of Food Timely food, Untimely food 2. Exercise : Frequency Intensity Time Type • Aerobics gym yoga exercise

31. CONT’ 6. Co morbid conditions: HT MAU LIPIDS BDR 7. Complication: IHD PDR NEPHROPATHY NEUROPATHY DFS PVD 8.Doctor factor: Clinical Inertia Selection of drug Dosage

32. HBA1C MAJESTIC IN THE MANAGEMENT OF DIABETES HBA1C MAJESTIC IN THE MANAGEMENT OF DIABETES

33. DIABETES MEANS CHRONIC HYPERGLYCEMIA WHAT WE TREAT IS ONLY ACUTE HYPERGLYCEMIA DIABETES MEANS CHRONIC HYPERGLYCEMIA WHAT WE TREAT IS ONLY ACUTE HYPERGLYCEMIA?

34. BLOOD SUGAR TELLS YOU THE DAY TO DAY VARIATION HBA1C IDENTIFIES THE OVER ALL FLUCCUATION OF BLOOD SUGAR BLOOD SUGAR TELLS YOU THE DAY TO DAY VARIATION HBA1C IDENTIFIES THE OVER ALL FLUCCATION OF BLOOD SUGAR

35. CLINICAL CASE STUDY MR.SANKARANARAYANAN 60YRS C/O SWELLING IN LEGS HIS HBA1C IS 11.0% CREA 2.4 WITH BDR ON THE DAY OF TESTING

36. CLINICAL CASE STUDY MRS.PADMINI 60 YRS ON THE DAY OF TESTING HAD BREAKFAST IN HOTEL HER FASTING WAS 140 POST PRANDIAL 260 & HBA1C 6.0%

37. HBA1C HELPS TO DECIDE ABOUT DIABETES IS UNDER CONTROL OR NOT PREDICTS FUTURE COMPLICATIONS HELPS TO DECIDE THE DIABETES MANAGEMENT

38. BLOOD SUGAR IS DYNAMIC KEEPS CHANGING WITH EACH MEAL BLOOD SUGAR GOES UP 3 TIMES A DAY 90 TIMES IN A MONTH WE CHECK BLOOD SUGAR ONCE IN A MONTH / FEW MONTHS & DIABETES IS TREATED ON PARTICULAR VALUE UNSCIENTIFIC NOT LOGIC

39. ROLE OF HBA1C • CONTROL < 7 % • NOT UNDER CONTROL > 7 % • PREDICTS FUTURE • COMPLICATION

40. DCCT , UKPDS STUDY DECIDE ABOUT THE DIABETES MANAGEMENT

41. LEVEL OF DECREASE IN HBA1C

42. CLINICAL DECESION MAKING

43. 1.SYMPTOMS 2.COMPLICATIONS 3.DURATION OF DIABETES 4.AGE 5.HBA1C 6.TYPE 1 OR TYPE 2 7.INSULIN DEFECIENCY OR INSULIN RESISTANCE 8.WHICH BLOOD SUGAR IS HIGH FASTING OR POST PRANDIAL 9.DIFFERENCE BETWEEN FASTING AND PP 10.DIABETES + OBESITY 11.DIABETES + HYPERTENSION 12.DIABETES + DYSLIPIDEMIA 13.PSYCO – SOCIO STATUS ,ECONOMIC STATUS 14.CO-OPERATION OF THE PERSON AND HIS FAMILY

44. SYMPTOMS CLINICAL SYMPTOMS ARE THE MOST IMPORTANT PARAMETER IN DECIDING THE TREATMENT PATHWAY Eg: POLYURIA,POLYPHYGIA,POLYDYPSIA,WT LOSS INDICATES A DECOMPENSATED SYMPTOMATIC DIABETES STATUS – NEEDS INSULIN THERAPY SEVERE NEUROPATHY – THE CHOICE IS INSULIN

45. COMPLICATIONS BASED ON THE MICRO OR MACRO VASCULAR COMPLICATION THE TREATMENT DECESION MAY DIFFER

46. DURATION OF DIABETES AT DIAGNOSIS 50 % OF BETA CELL IS LOST LONGER THE DURATION MORE LIKELY REQUIRE INSULIN THERAPY

47. AGE • YOUNG AGE ONSET • MIDDLE AGE ONSET / CLASSICAL ONSET • OLD AGE ONSET YOUNG AGE ONSET MAY REQUIRE A TIGHT CONTROL

48. HBA1C INDICATES A CHRONIC HYPERGLYCEMIA HBA1C > 10% MAY REQUIRE INSULIN THERAPY

49. INSULIN RESISTANCE OR INSULIN DEFECIENCY WHICH IS PREDOMINANT ?

50. FASTING OR POST PRANDIAL WHICH BLOOD SUGAR IS HIGH? WHAT IS THE DIFFERENCE BETWEEN FASTING AND POST PRANDIAL? Eg: BASAL INSULIN TO CONTROL THE FASTING BOLUS TO CONTROL THE POST PRANDIAL