Multicentric Castleman Disease: unusual clinical presentations and outcome in 6 recent cases Ch. Martin, D. Konopnicki, S. De Wit, N. Clumeck Saint-Pierre University Hospital, Brussels, Belgium. E-mail : firstname.lastname@example.org. 6 patients. Background
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Multicentric Castleman Disease: unusual clinical presentations and outcome in 6 recent cases
Ch. Martin, D. Konopnicki, S. De Wit, N. Clumeck
Saint-Pierre University Hospital, Brussels, Belgium. E-mail : email@example.com
We describe 6 HIV-positive patients with MCD +/- plasmablastic lymphoma transformation diagnosed and managed in our institution during the last 3 years (2008-2011) and compare our data’s with series of MCD described in the literature.
4 homosexuel men
3 MCD with
1 MCD with
1 fulminant death
3 CR alive:
FU 29-16-16 months
1 CR alive:
FU 18 months
Death at13 months.
R-CHOP= Rituximab and CHOP. CR = Complete remission. PR= Partial remission
Unusual findings: 2/6 heterosexual African women, 4/6 HIV-RNA<20 under HAART
1/2 flare-up of symptoms after HAART initiation, coexistent lymphoma 66%, 4/4 lymphomas treated with R-CHOP alive.