Challenge of personalized health care: To what extent is medicine already individualized and what ar...
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Author: Walter Fierz Presented by Xiaomin Xu For Journal Club on Sep.13,2005 PowerPoint PPT Presentation


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Challenge of personalized health care: To what extent is medicine already individualized and what are the future trends?. Author: Walter Fierz Presented by Xiaomin Xu For Journal Club on Sep.13,2005. Backgound. Before the advent of scientific medicine Lack of standardization

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Author: Walter Fierz Presented by Xiaomin Xu For Journal Club on Sep.13,2005

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Author walter fierz presented by xiaomin xu for journal club on sep 13 2005

Challenge of personalized health care: To what extent is medicine already individualized and what are the future trends?

Author: Walter Fierz

Presented by Xiaomin Xu

For Journal Club on Sep.13,2005


Backgound

Backgound

  • Before the advent of scientific medicine

    • Lack of standardization

    • Individualize medical care

  • Introduction of the scientific medicine

    • Personal aspects of treatment were endangered

  • Challenge: regain individualism on a scientific basis


Personalized medicine

Personalized medicine

  • Occurred at post-genomic era

  • Individualized medicine is not new

  • New are: Molecular diagnostics based on comprehensive and high-throughput genetic testing & pharmacogenomics

  • Focus of this article: infectious diseases and clinical immunological disorders


Six dimensions of pm

Six dimensions of PM

  • Disease: disease evolution

  • Environment: the infecting microbe

  • Genes: the molecular traits and mechanisms underlying the individual characteristics of both the patient and the microbe


Six dimensions of pm cont

Six dimensions of PM (Cont.)

  • Medication: drug development

  • Health care: health-care process

  • Information management: patient-specific and knowledge-based

  • Properties along these six dimensions are not independent from each other


Individual character of infectious diseases

Individual character of infectious diseases

  • Interaction between host and microbes is very individual

  • Individuality: based on many factors

  • Molecular technology has been introduced into the third dimension


Individual character of immune responses

Individual character of immune responses

  • Innate immune system and adaptive immune system both show high degree of polymorphism

  • Overwhelming complexity of the immune system make personalizing prevention and treatment difficult


Within health care process

Within health care process

  • Personalized medicine and patient-centered care are mutually supportive.

  • Put emphasis on the integration of disparate personalized medical approaches and on the integration of fragmented personal records.

  • Personalized information management

  • Clinical laboratory should provide electronic links between personal lab data and electronic information from digital libraries and databases.


Social and ethical risks

Social and ethical risks

  • Personal values are at stake: privacy, protection of minorities, prevention of discrimination

  • Regulation:

    • Inform consent in the diagnostic process

    • Clinical lab as trusted intermediaries

    • Legal protection

    • Protect genetic minorities

    • Rational and irrational discrimination


Conclusions

Conclusions

  • Personalized medicine is promising

  • Challenge is to adapt the health-care process to the needs of personalized medicine and to cope with its social risks


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