Histology for Pathology Respiratory System. Theresa Kristopaitis , MD Associate Professor Director of Mechanisms of Human Disease Kelli A. Hutchens, MD, FCAP Assistant Professor Assistant Director of Mechanisms of Human Disease Loyola Stritch School of Medicine. Objectives.
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Theresa Kristopaitis, MD
Director of Mechanisms of Human Disease
Kelli A. Hutchens, MD, FCAP
Assistant Director of Mechanisms of Human Disease
Loyola Stritch School of Medicine
Hyaline Cartilage Plates
Smooth muscle band
An electron microscope (EM) uses an electron beam to illuminate a specimen and produce a magnified image. Is able to achieve magnifications up to 10,000,000 x thus it is very useful to look at the ultrastructural characteristics of a cell.
Electron micrograph (EM) of the respiratory mucosa. You can see the ciliated cells with interspersed Clara cells.
b = respiratory bronchiole with alveolus (a) in its wall. Most of the wall of the bronchiole has a definite line of dark along it, signifying a cuboidal epithelium d & c = alveolar duct. Its wall consists almost entirely of alveoli, which have only a simple squamous lining, too flat to be visible here.
e = alveoli (the smallest respiratory units)
f = blood vessel (branch of pulmonary artery still)
Type I Pneumocytes
Type II Pneumocyte
EM showing basal lamina (1) between squamous alveolar epithelium (2 = Type I cell) and capillary endothelium (3). The nucleus at upper right belongs to the endothelial cell lining the capillary. The dark structure is a red blood cell. The capillary plus the alveolar linings on both sides constitute the inter alveolar septum that lies between two alveolar spaces.